Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
A proteome-scale map of the human interactome network.
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Armadillo repeat-containing protein 1 is a dual localization protein associated with mitochondrial intermembrane space bridging complex.
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ARMC1 is a peripheral outer-membrane MICOS/MIB component needed for mitochondrial distribution.
"ArmC1, therefore, represents a novel peripheral component of the MICOS/MIB complex with an unusual localization to both cytosol and mitochondria, which might play a role in cellular distribution of mitochondria."
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
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High-confidence human mitochondrial proteome.
"We classified >8,000 proteins in mitochondrial preparations of human cells and defined a mitochondrial high-confidence proteome of >1,100 proteins (MitoCoP)."
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Multimodal cell maps as a foundation for structural and functional genomics.
ARMC1 partitions between distinct complexes and assembles MIRO with MTFR to control mitochondrial distribution.
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ARMC1 assembles MIRO with MTFR to control mitochondrial distribution.
"In one complex, the mitochondrial trafficking adaptor MIRO recruits ARMC1, which mediates the assembly of a mitochondrial fission regulator (MTFR)."
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The HMA-like domain lacks metal-coordinating cysteines.
"ARMC1 contains an N-terminal helical domain with an Armadillo motif, a heavy metal-associated–like (HMAL) domain that lacks cysteines in the positions required for metal coordination, and a short, conserved C-terminal domain (CTD) (fig."
Natural Variation in a Dendritic Scaffold Protein Remodels Experience-Dependent Plasticity by Altering Neuropeptide Expression.
UniProt entry Q9NVT9 (ARMC1_HUMAN)
Affinage mechanistic annotation for ARMC1 (human)