Generated Falcon deep research at PIK3CD-deep-research-falcon.md and used it with
UniProt plus cached publications to complete the initialized GO review.
Core synthesis: PIK3CD encodes p110delta, a leukocyte-enriched class IA PI3K
catalytic subunit. The central molecular function is PI(4,5)P2 3-kinase
activity producing PIP3 in p85-family regulatory complexes at receptor-activated
membranes. Falcon summarizes this as: [file:human/PIK3CD/PIK3CD-deep-research-falcon.md
"PIK3CD encodes the catalytic subunit p110δ of class IA phosphoinositide
3-kinase (PI3Kδ), a lipid kinase that produces PI(3,4,5)P3 (PIP3) at
membranes downstream of receptor signaling in immune cells, particularly in
lymphocytes."] Direct biochemical work also reports that recombinant p110delta
phosphorylates phosphatidylinositol and associates with p85 PMID:9235916.
The most informative process terms are PI3K/AKT signaling plus immune receptor
contexts, especially BCR, TCR, and CD28. Falcon frames the receptor context as
[file:human/PIK3CD/PIK3CD-deep-research-falcon.md "In immune cells, class IA PI3K
(including p110δ) propagates signaling downstream of BCR, TCR, CD28, ICOS,
CD19, BAFF-R, CD40"] and UniProt separately records BCR and TCR requirements
[file:human/PIK3CD/PIK3CD-uniprot.txt "Required for B-cell receptor (BCR) signaling."]
[file:human/PIK3CD/PIK3CD-uniprot.txt "Required for T-cell receptor (TCR) signaling."].
Broad immune, chemotaxis, endothelial migration, angiogenesis, mast-cell,
neutrophil, NK-cell, and cytokine-production annotations were retained as
non-core where supported. The main evidence is that PI3Kdelta participates in
multiple leukocyte outputs PMID:20940048 and myeloid
activities PMID:20940048.
Several terms were deliberately modified or marked over-annotated:
The preserved acquisition baseline and raw-file hashes are in .cache/module-audit-logs/b-cell-panel-baseline.json. This review covers all annotations, including functions outside B-cell signaling. Normal acquisition and actual provider attempts are recorded in b-cell-acquisition-report.md and b-cell-fetch/provider-publication-results.json; provider failures are not research reports. Existing genuine exact-target reports, where available, are discovery aids. Original machine annotation payloads and raw source records will be preserved.
p110δ catalyzes the major PIP3-generating class IA reaction, but its experimentally documented PI and PI4P substrate activities are not false. PI3P biosynthesis and the corresponding kinase activities are retained as secondary chemistry. PMID:10064595 identifies Ser1039 autophosphorylation, so the general protein-phosphorylation row is refined to autophosphorylation and the serine kinase activity is preserved. Phosphosite evidence in cells does not automatically identify the in-cell phosphodonor.
The full angiogenesis paper PMID:31915155 combines native human endothelial experiments with mouse oxygen-induced retinopathy, supporting a specific angiogenesis refinement of generic development/morphogenesis. PMID:22079609 supports selected protein-expression effects, while the stromal chemokine study PMID:24009720 is native mouse evidence and is labeled accordingly. Integral ATP binding is core. Neutrophil positive-apoptosis claims remain unresolved because the accessible PMID:25339672 evidence does not isolate the delta-specific mechanism and death mode. These are claim-level uncertainties, not penalties for an evidence code.
All 114 original annotation payloads, including qualifiers and any negation flags, were preserved; no NEW assertions were added. Normal source acquisition and actual provider outcomes are retained in the acquisition logs. Failed provider calls were not replaced with fabricated reports. Source-access limits are recorded above and in the individual row reasons; partial publisher pages and captcha responses were not treated as full articles. The six-member focused strict/schema, GO-term and source-quotation check passed with zero errors and warnings before final packaging; the final package reruns those checks after finding additions. Record-section backfill, HTML rendering, helper-generated Codex provenance and exact payload/raw-hash checks accompany the package.