Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Automatic Gene Ontology annotation based on Rhea mapping
Combined Automated Annotation using Multiple IEA Methods
Caenorhabditis elegans lin-45 raf is essential for larval viability, fertility and the induction of vulval cell fates.
The ERK MAP kinase cascade mediates tail swelling and a protective response to rectal infection in C. elegans.
SEL-10/Fbw7-dependent negative feedback regulation of LIN-45/Braf signaling in C. elegans via a conserved phosphodegron.
SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans.
UniProtKB Q07292 KRAF1_CAEEL record
The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans.
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RNAi of lin-45, mek-2 or mpk-1 reduces adult lifespan; the ERK cascade promotes longevity through SKN-1 and DAF-16.
"We find that RNAi of three genes, which constitute the ERK cascade (lin-45/RAF1, mek-2/MEK1/2, and mpk-1/ERK1/2), results in reduction of life span."
WormBase gene description for lin-45 (worm)