Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Combined Automated Annotation using Multiple IEA Methods

Fourteen years' follow-up of an autoimmune patient lacking the CD3 gamma subunit of the T-lymphocyte receptor.

The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain.

Contribution of CD3 gamma to TCR regulation and signaling in human mature T lymphocytes.

TCR dynamics in human mature T lymphocytes lacking CD3 gamma.

Activation-induced ubiquitination of the T cell antigen receptor.

Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif.

Stoichiometry of the murine gammadelta T cell receptor.

Regulatory mechanisms in T cell receptor signalling.

T cell receptor signaling for γδT cell development.

Structural basis of assembly of the human T cell receptor-CD3 complex.

A reference map of the human binary protein interactome.

Role of CD3 gamma in T cell receptor assembly.

Assembly of the TCR/CD3 complex: CD3 epsilon/delta and CD3 epsilon/gamma dimers associate indistinctly with both TCR alpha and TCR beta chains. Evidence for a double TCR heterodimer model.

TCR complex interacts with peptide antigen-presenting MHC Class I

Phosphorylation of ITAM motifs in CD3 complexes

Phosphorylation of ZAP-70 by Lck

Activation of ZAP-70

Dephosphorylation of Lck-pY505 by CD45

Phosphorylation of SLP-76

Inactivation of Lck by Csk

Phosphorylation of TBSMs in LAT

Phosphorylation of PLC-gamma1

Activation of Lck

Change of PKC theta conformation

Recruitment of ZAP-70 to phosphorylated ITAMs

Phosphorylation and activation of PLCG

Recruitment of PLCgamma to membrane

PI3K phosphorylates PIP2 to PIP3

Release of PLCG from FCGR

PI3K binds to p-6Y-SYK

Activation of RAC1 by VAV

Recruitment of SYK to phosphorylated ITAMs

Phosphorylation of VAV

Cross-linking of FCGRIA with IgG-coated Ag

Cross-linking of FCGRIIIA with IgG-coated Ag

Recruitment of VAV1 to p-6Y-SYK

Sequestering and phosphorylation Fc gamma receptors in the lipid rafts

Activation of RAC1 by CRKII:DOCK180:ELMO

Role of myosins in phagosome formation

Recruitment of CRKII:DOCK180:ELMO complex to FCGR

Dephosphorylation of CD3-zeta by PD-1 bound phosphatases

TCR binds self-lipid-based antigen via CD1

TCR binds microbial lipid-based antigen via CD1

Inactivation of LCK by PTPN22

PTPN22 dephosphorylates ZAP70

AP-2 directly binds some endocytic cargo

F- and N- BAR domain proteins bind the clathrin-coated pit

CLASP proteins and cargo are recruited to the nascent clathrin-coated pit

Clathrin recruits PIK3C2A

Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2

SNX9 recruits components of the actin polymerizing machinery

BAR domain proteins recruit dynamin

SYNJ hydrolyze PI(4,5)P2 to PI(4)P

Endophilins recruit synaptojanins to the clathrin-coated pit

HSPA8-mediated ATP hydrolysis promotes vesicle uncoating

Clathrin recruits auxilins to the clathrin-coated vesicle

Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle

Dynamin-mediated GTP hydrolysis promotes vesicle scission

Dissociation of clathrin-associated proteins

Dissociation of AAK1 and dephosphorylation of AP-2 mu2

RAB5 and GAPVD1 bind AP-2

Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK

Opsonized leishmania amastigote binds FCGR3

Recruitment of PLCgamma to membrane due to FCGR3A effect

Release of PLCG from FCGR3A

SYK binds IgG:Lma antigens:FCGR3A:p-CD3 dimers

Src phosphorylates CD3 dimers in IgG:Lma antigens:FCGR3A:CD3 dimers

Phosphorylation and activation of PLCG due to FCGR3A effect

IgG:Lma antigens binds FCGR3A:CD3 dimers

p-6Y-SYK phosphorylates VAV1,2,3

CRKII:DOCK180:ELMO binds FCGR3A

DOCK180 exchanges GTP for GDP on RAC1:GDP

p-VAV1,2,3 exchanges GTP for GDP on RAC1:GDP

VAV1,2,3:PI(3,4,5)P3 binds p-6Y-SYK

IgG:Leishmania surface:FCGR3A translocates from plasma membrane to the parasitophorous vacuole

The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.

CD3 gamma contains a phosphoserine-dependent di-leucine motif involved in down-regulation of the T cell receptor.

A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains.

Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3.

Differential biological role of CD3 chains revealed by human immunodeficiencies.

Structures of human γδ T cell receptor-CD3 complex.

Plasticity and rigidity in adaptor protein-2-mediated internalization of the TCR:CD3 complex.

The protein interactions of the immunoglobulin receptor family tyrosine-based activation motifs present in the T cell receptor zeta subunits and the CD3 gamma, delta and epsilon chains.

Patients with CD3G mutations reveal a role for human CD3γ in T(reg) diversity and suppressive function.

A Novel CD3G Mutation in a Taiwanese Patient With Normal T Regulatory Function Presenting With the CVID Phenotype Free of Autoimmunity-Analysis of all Genotypes and Phenotypes.

Falcon deep research report for human CD3G

Regulation and function of the CD3gamma DxxxLL motif: a binding site for adaptor protein-1 and adaptor protein-2 in vitro.