Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Crystal structure of aurora-2, an oncogenic serine/threonine kinase.
Aurora-A kinase interacting protein (AIP), a novel negative regulator of human Aurora-A kinase.
Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells.
Structural basis of Aurora-A activation by TPX2 at the mitotic spindle.
Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A.
SAR and inhibitor complex structure determination of a novel class of potent and specific Aurora kinase inhibitors.
Mitotic activation of the kinase Aurora-A requires its binding partner Bora.
HEF1-dependent Aurora A activation induces disassembly of the primary cilium.
Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis.
A role for IkappaB kinase 2 in bipolar spindle assembly.
Astrin regulates Aurora-A localization.
Plk1 regulates mitotic Aurora A function through betaTrCP-dependent degradation of hBora.
Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry.
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery.
Modulation of kinase-inhibitor interactions by auxiliary protein binding: crystallography studies on Aurora A interactions with VX-680 and with TPX2.
Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A.
Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma.
Structure-based drug design of novel Aurora kinase A inhibitors: structural basis for potency and specificity.
A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function.
A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.
Aurora-A overexpression in mouse liver causes p53-dependent premitotic arrest during liver regeneration.
Aurora A, centrosome structure, and the centrosome cycle.
A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2.
Systematic analysis of human protein complexes identifies chromosome segregation proteins.
Solution structure of human growth arrest and DNA damage 45alpha (Gadd45alpha) and its interactions with proliferating cell nuclear antigen (PCNA) and Aurora A kinase.
A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers.
Functional characterization of AIBp, a novel Aurora-A binding protein in centrosome structure and spindle formation.
Pitchfork regulates primary cilia disassembly and left-right asymmetry.
The nuclear scaffold protein SAF-A is required for kinetochore-microtubule attachment and contributes to the targeting of Aurora-A to mitotic spindles.
Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.
Identification of Ski as a target for Aurora A kinase.
PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer.
A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases.
Aurora-A phosphorylates hnRNPK and disrupts its interaction with p53.
RALA and RALBP1 regulate mitochondrial fission at mitosis.
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.
Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer.
Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase A oncogene.
Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest.
Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73.
The CUL3-KLHL18 ligase regulates mitotic entry and ubiquitylates Aurora-A.
Protein phosphorylation profiling using an in situ proximity ligation assay: phosphorylation of AURKA-elicited EGFR-Thr654 and EGFR-Ser1046 in lung cancer cells.
Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma.
NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner.
Phosphorylation of multifunctional nucleolar protein nucleophosmin (NPM1) by aurora kinase B is critical for mitotic progression.
Depletion of IK causes mitotic arrest through aberrant regulation of mitotic kinases and phosphatases.
Drugging MYCN through an allosteric transition in Aurora kinase A.
CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly.
Phosphorylation of SAF-A/hnRNP-U Serine 59 by Polo-Like Kinase 1 Is Required for Mitosis.
Aurora-A regulates MCRS1 function during mitosis.
N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer.
Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors.
Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.
Architecture of the human interactome defines protein communities and disease networks.
Human nuclear RNAi-defective 2 (NRDE2) is an essential RNA splicing factor.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
SOX9 is regulated by AURKA in response to Helicobacter pylori infection via EIF4E-mediated cap-dependent translation.
Cell cycle-dependent expression and spindle pole localization of a novel human protein kinase, Aik, related to Aurora of Drosophila and yeast Ipl1.
Association of cell cycle proteins with the APC/C:Cdh1 complex
Degradation of multiubiquitinated cell cycle proteins
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex
AJUBA facilitates AURKA autophosphorylation
AJUBA binds centrosome-associated AURKA
AURKA phosphorylates PLK1
BORA binds PLK1 and AURKA
Regulation of TP53 Activity through Phosphorylation
AURKA phosphorylates TP53
TPX2 binds AURKA at centrosomes
TPX2 promotes AURKA autophosphorylation
AURKA phosphorylates PHLDA1
SCF-FBXL7 ubiquitinates AURKA
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
UniProt entry O14965 (AURKA_HUMAN)
CEP215 and AURKA regulate spindle pole focusing and aMTOC organization in mouse oocytes.
Structural basis for CEP192-mediated regulation of centrosomal AURKA.
Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype.
Affinage mechanistic annotation for AURKA (human)