Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on inter-ontology links
Combined Automated Annotation using Multiple IEA Methods
Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype.
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Beta2 subunit is obligatory for functional calcium channel expression
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Coexpression with alpha1D and alpha2b produces dihydropyridine-sensitive L-type channel
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Beta2 potentiates channel expression and increases peak calcium current
Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death.
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CACNB2 S481L mutation causes Brugada syndrome with shortened QT
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Beta2b is part of cardiac L-type calcium channel complex
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Mutations affect channel trafficking and function
Dominant negative suppression of Rad leads to QT prolongation and causes ventricular arrhythmias via modulation of L-type Ca2+ channels in the heart.
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CACNB2 interacts with RRAD (Ras associated with diabetes)
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Rad regulates L-type calcium channel expression via CaVbeta
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Interaction affects channel trafficking to plasma membrane
Ca(V)1.1: The atypical prototypical voltage-gated Ca²⁺ channel.
Direct interaction of CaVβ with actin up-regulates L-type calcium currents in HL-1 cardiomyocytes.
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CaVbeta2 directly binds actin filaments
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Interaction promotes channel trafficking to plasma membrane
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Overexpression increases L-type current by increasing membrane channels
Voltage-gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology.
A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors.
A reference map of the human binary protein interactome.
Mechanisms and Regulation of Cardiac Ca(V)1.2 Trafficking.
Cloning and characterization of a Lambert-Eaton myasthenic syndrome antigen.
Effects of temperature on human L-type cardiac Ca2+ channels expressed in Xenopus oocytes.
LTCC multimer transports Ca2+ from extracellular region to cytosol
Class IV antihypertensives bind LTCC multimer