GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000108
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
GO_REF:0000121
RGD ISO annotations to rat from other mammalian species
PMID:10027300
Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1.
PMID:10340301
The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits.
PMID:10414981
Association of AMPA receptors with a subset of glutamate receptor-interacting protein in vivo.
PMID:10558890
rDLG6: a novel homolog of Drosophila DLG expressed in rat brain.
PMID:10701825
Differential synaptic localization of the glutamate transporter EAAC1 and glutamate receptor subunit GluR2 in the rat hippocampus.
PMID:10704491
Regulation of kinetic properties of GluR2 AMPA receptor channels by alternative splicing.
PMID:10856222
Disruption of AMPA receptor GluR2 clusters following long-term depression induction in cerebellar Purkinje neurons.
PMID:11007883
Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins.
PMID:11100149
Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization.
PMID:11348590
Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons.
PMID:11466413
PICK1 targets activated protein kinase Calpha to AMPA receptor clusters in spines of hippocampal neurons and reduces surface levels of the AMPA-type glutamate receptor subunit 2.
PMID:11773314
Voltage and concentration dependence of Ca(2+) permeability in recombinant glutamate receptor subtypes.
PMID:11836517
The structure and function of glutamate receptor ion channels.
PMID:11891216
The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs.
PMID:11931740
Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting.
PMID:11931741
NSF ATPase and alpha-/beta-SNAPs disassemble the AMPA receptor-PICK1 complex.
PMID:11978826
Differential palmitoylation directs the AMPA receptor-binding protein ABP to spines or to intracellular clusters.
PMID:12077196
Alpha7 nicotinic acetylcholine receptors occur at postsynaptic densities of AMPA receptor-positive and -negative excitatory synapses in rat sensory cortex.
PMID:12130635
Brain-derived neurotrophic factor regulates surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptors by enhancing the N-ethylmaleimide-sensitive factor/GluR2 interaction in developing neocortical neurons.
PMID:12554656
Regulated delivery of AMPA receptor subunits to the presynaptic membrane.
PMID:12629171
Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting.
PMID:14597197
Brain-derived neurotrophic factor signal enhances and maintains the expression of AMPA receptor-associated PDZ proteins in developing cortical neurons.
PMID:15269270
Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit 1 synaptic expression.
PMID:15610164
Presynaptic localization of an AMPA-type glutamate receptor in corticostriatal and thalamostriatal axon terminals.
PMID:15844209
Ionotropic glutamate receptors are expressed in GABAergic terminals in the rat superficial dorsal horn.
PMID:15965473
GRIP1 controls dendrite morphogenesis by regulating EphB receptor trafficking.
PMID:16037816
Interactions between NEEP21, GRIP1 and GluR2 regulate sorting and recycling of the glutamate receptor subunit GluR2.
PMID:16108831
Identification of immunoglobulin superfamily 11 (IGSF11) as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas.
PMID:16157387
Generation of lentiviral transgenic rats expressing glutamate receptor interacting protein 1 (GRIP1) in brain, spinal cord and testis.
PMID:16311338
Nucleus accumbens long-term depression and the expression of behavioral sensitization.
PMID:16338934
Involvement of myosin Vb in glutamate receptor trafficking.
PMID:1653450
Identification of a site in glutamate receptor subunits that controls calcium permeability.
PMID:16903873
Ultrastructural localisation and differential agonist-induced regulation of AMPA and kainate receptors present at the presynaptic active zone and postsynaptic density.
PMID:17207780
Distribution of NMDA and AMPA receptor subunits at thalamo-amygdaloid dendritic spines.
PMID:17289840
Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2.
PMID:17329210
LTP inhibits LTD in the hippocampus via regulation of GSK3beta.
PMID:17506699
The cell biology of synaptic plasticity: AMPA receptor trafficking.
PMID:17914463
Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes.
PMID:18297063
Inhibition of Arp2/3-mediated actin polymerization by PICK1 regulates neuronal morphology and AMPA receptor endocytosis.
PMID:18817736
AMPA receptor subunit-specific regulation by a distinct family of type II TARPs.
PMID:19160501
Serine phosphorylation of ephrinB2 regulates trafficking of synaptic AMPA receptors.
PMID:19234459
Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5.
PMID:19265014
Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors.
PMID:19321442
PICK1-mediated glutamate receptor subunit 2 (GluR2) trafficking contributes to cell death in oxygen/glucose-deprived hippocampal neurons.
PMID:19461580
Crystal structure and association behaviour of the GluR2 amino-terminal domain.
PMID:19591855
Long-term exposure to endogenous levels of tributyltin decreases GluR2 expression and increases neuronal vulnerability to glutamate.
PMID:19617541
Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ions.
PMID:19674091
Nucleus accumbens neurons exhibit synaptic scaling that is occluded by repeated dopamine pre-exposure.
PMID:19942860
Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling.
PMID:19946266
X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor.
PMID:20018661
Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD.
PMID:20032460
Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption.
PMID:20802490
Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation.
PMID:21172611
Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins.
PMID:21187978
Synaptic neurotransmission depression in ventral tegmental dopamine neurons and cannabinoid-associated addictive learning.
PMID:21317873
Subunit-selective N-terminal domain associations organize the formation of AMPA receptor heteromers.
PMID:21376300
Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability.
PMID:21496646
The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior.
PMID:21639859
Crystal structure of the glutamate receptor GluA1 N-terminal domain.
PMID:21807099
mGluR and NMDAR activation internalize distinct populations of AMPARs.
PMID:21846932
Mechanism of AMPA receptor activation by partial agonists: disulfide trapping of closed lobe conformations.
PMID:21847098
PIKE-mediated PI3-kinase activity is required for AMPA receptor surface expression.
PMID:22915106
PICK1 mediates transient synaptic expression of GluA2-lacking AMPA receptors during glycine-induced AMPA receptor trafficking.
PMID:23460828
Acute BDNF treatment upregulates GluR1-SAP97 and GluR2-GRIP1 interactions: implications for sustained AMPA receptor expression.
PMID:24418105
Direct association of the unique C-terminal tail of transmembrane AMPA receptor regulatory protein γ-8 with calcineurin.
PMID:24673938
L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain.
PMID:24712995
BDNF contributes to both rapid and homeostatic alterations in AMPA receptor surface expression in nucleus accumbens medium spiny neurons.
PMID:25129673
Impact of combined prenatal ethanol and prenatal stress exposures on markers of activity-dependent synaptic plasticity in rat dentate gyrus.
PMID:26109571
Activity-dependent synaptic GRIP1 accumulation drives synaptic scaling up in response to action potential blockade.
PMID:26595655
Synaptic adhesion molecule IgSF11 regulates synaptic transmission and plasticity.
PMID:27756895
MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density.
PMID:28057533
Presynaptic PICK1 facilitates trafficking of AMPA-receptors between active zone and synaptic vesicle pool.
PMID:29134962
Role of Glutamatergic Projections from the Ventral CA1 to Infralimbic Cortex in Context-Induced Reinstatement of Heroin Seeking.
PMID:30545844
Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting.
PMID:30872532
Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP γ8.
PMID:31925409
Cryo-EM structures of the ionotropic glutamate receptor GluD1 reveal a non-swapped architecture.
PMID:32071234
Tyrosine phosphorylation of the AMPA receptor subunit GluA2 gates homeostatic synaptic plasticity.
PMID:32948689
GRIP1 regulates synaptic plasticity and learning and memory.
PMID:37190555
Intravenous Injection of GluR2-3Y Inhibits Repeated Morphine-Primed Reinstatement of Drug Seeking in Rats.
PMID:9069286
GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors.
PMID:9647694
CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins.
PMID:9697854
NSF binding to GluR2 regulates synaptic transmission.
PMID:9697855
The AMPA receptor GluR2 C terminus can mediate a reversible, ATP-dependent interaction with NSF and alpha- and beta-SNAPs.
PMID:9768844
Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP.
Reactome:R-RNO-9022366
Gria2 gene expression is inhibited by Mecp2:Sin3a complex
file:rat/Gria2/Gria2-uniprot.txt
UniProtKB P19491 (GRIA2_RAT) flat file
file:rat/Gria2/Gria2-deep-research-manual.md
Manual literature synthesis for rat Gria2