Men-b notes

• 2026-10-09: Initial review of Men-b (E1JIZ4; CG5889; dME3), malic enzyme paralog of Men.
• N-terminus MFSRPSLCGTVGKLCRCGTSATGK... looks like a mitochondrial presequence (not annotated as
  TRANSIT in UniProt).
• Murari et al. 2022 PMID:35544578: "CG5889 (Men-b) is the Drosophila ortholog of ME3." and
  "ME1 and ME3 use NADP+ as a cofactor, while ME2 can use either NADP+ or NAD+." Flight-muscle RNAi:
  "We conclude that disruption of dME3 impairs the biogenesis or stability of the Q- and N-modules to
  trigger a disruption in CI assembly." and "Samples expressing RNAi constructs for dME3 were analyzed
  2 days after eclosure due to early lethality." (found via falcon deep research).
• No NEW complex I assembly annotation proposed: the effect is attributed to NADPH supply, an
  indirect role (enzyme does not do assembly work).
• Glucome RNAi screen IMP glucose homeostasis PMID:25994086 kept as non-core.
• Falcon deep research also cites 2024 bioRxiv preprints (tissue metabolic models; high-sugar
  macrophage RNA-seq) - not used.