Gene Ontology annotation through association of InterPro records with GO terms

Gene Ontology annotation based on Enzyme Commission mapping

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

GO_REF:0000116

Automatic Gene Ontology annotation based on Rhea mapping

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

PMID:107465

A quantitative study of the glia of the Purkinje cell layer of the cerebellum in mammals.

The identifier is unrelated to CIITA; the intended MGI reference is PMID:16280321.

PMID:10938133

Associations and interactions between bare lymphocyte syndrome factors.

CIITA associates with the RFX complex, with RFX5 regions contributing to the interaction.

PMID:11172716

Transcriptional coactivator, CIITA, is an acetyltransferase that bypasses a promoter requirement for TAF(II)250.

The original abstract reports CIITA acetyltransferase activity and bypass of a TAFII250 requirement.

PMID:15771576

CATERPILLER: a novel gene family important in immunity, cell death, and diseases.

The family review provides context for CIITA as a transcriptional regulator rather than a sequence-specific DNA-binding factor.

PMID:16600381

ZXDC, a novel zinc finger protein that binds CIITA and activates MHC gene transcription.

ZXDC binds CIITA and promotes MHC transcription, with a mapped C-terminal interaction region.

PMID:17493635

The zinc finger proteins ZXDA and ZXDC form a complex that binds CIITA and regulates MHC II gene transcription.

ZXDA and ZXDC form a complex that associates with CIITA and supports MHC II expression.

PMID:19041327

HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells.

HDAC2 antagonizes CIITA-dependent MHC II activation and collagen repression while deacetylating CIITA; it is not demonstrated recruited repression machinery.

PMID:20639463

NLR family member NLRC5 is a transcriptional regulator of MHC class I genes.

CIITA activates class I promoter reporters and increases class I expression, while more strongly promoting class II expression.

PMID:21890893

SIRT1 links CIITA deacetylation to MHC II activation.

SIRT1 associates with and deacetylates CIITA, supporting its stability, nuclear accumulation and MHC II activation.

PMID:23007646

PML promotes MHC class II gene expression by stabilizing the class II transactivator.

PML supports CIITA stability and recruitment to nuclear bodies, enhancing MHC class II expression.

PMID:24036077

Transcriptional coactivator CIITA, a functional homolog of TAF1, has kinase activity.

CIITA preparations phosphorylate H2B Ser36, TAF7 and RAP74 and acetylate histones H3/H4; autophosphorylation changes TAF7 association and acetyltransferase activity in vitro.

PMID:32855215

MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses.

CIITA-dependent transcription induces antiviral resistance through downstream genes including CD74 p41, which mediates the protease-related viral-fusion block.

PMID:7749984

Activation of class II MHC genes requires both the X box region and the class II transactivator (CIITA).

MHC II activation depends on CIITA and the promoter X-box region, with mutant products impairing activation.

PMID:8402893

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome).

CIITA complementation restores MHC class II expression in human bare-lymphocyte-syndrome cells.

PMID:9171108

The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32.

The CIITA N-terminal activation region interacts with TAF9 and couples that interaction to transcriptional activation.

Reactome:R-HSA-1031716

Expression of IFNG-stimulated genes

The human CIITA output entity is explicitly placed in nucleoplasm.

PMID:16280321

The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons.

Hsp90/CDC37 inhibition suppresses IFN-induced CIITA expression through upstream signaling; CIITA abundance is an experimental response readout.

PMID:10464099

GTP binding by class II transactivator: role in nuclear import.

CIITA binds GTP, with motif-mutant and protein-expression controls; the recovered page does not establish GTPase activity.

PMID:40608405

The human cytomegalovirus-encoded pUS28 antagonizes CD4+ T cell recognition by targeting CIITA.

The viral pUS28 protein antagonizes CIITA-dependent antigen-presentation gene expression by reducing CIITA protein abundance.

file:human/CIITA/CIITA-source-evidence.json

CIITA source identity and assay scope index