Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Combined Automated Annotation using Multiple IEA Methods
Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster.
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Human GLIPR1L1 is testis specific and has two alternatively spliced isoforms.
"GLIPR1L1 has two and GLIPR1L2 has five differentially spliced isoforms"
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The tested human tissue panel showed testis-specific GLIPR1L1 expression.
"GLIPR1L1 is testis-specific"
Glioma pathogenesis-related 1-like 1 is testis enriched, dynamically modified, and redistributed during male germ cell maturation and has a potential role in sperm-oocyte binding.
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Mouse GLIPR1L1 is testis enriched and glycosylated during spermatogenesis.
"Herein we cloned mouse Glipr1l1 and have shown it has a testis-enriched expression profile"
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Mouse GLIPR1L1 localizes to the connecting piece and anterior sperm head.
"GLIPR1L1 is posttranslationally modified by N-linked glycosylation during spermatogenesis and ultimately becomes localized to the connecting piece of elongated spermatids and sperm"
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Antibody-based assays suggested a role in sperm binding to the zona pellucida.
"Zona pellucida binding assays indicate that GLIPR1L1 has a role in the binding of sperm to the zona pellucida surrounding the oocyte"
Bovine sperm raft membrane associated Glioma Pathogenesis-Related 1-like protein 1 (GliPr1L1) is modified during the epididymal transit and is potentially involved in sperm binding to the zona pellucida.
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Bovine GLIPR1L1 is a GPI-anchored sperm plasma-membrane protein.
"GliPr1L1 is glycosyl phosphatidyl inositol (GPI) anchored to caput and cauda spermatozoa"
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Bovine GLIPR1L1 partitions into sperm lipid-raft fractions.
"GliPr1L1 was immunodetectable in the low buoyant density fractions where lipid rafts are distributed"
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Bovine GLIPR1L1 localizes to the sperm equatorial segment and neck.
"GliPr1L1 was localized on sperm equatorial segment and neck"
CD9-positive microvesicles mediate the transfer of molecules to Bovine Spermatozoa during epididymal maturation.
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GLIPR1L1 is enriched in a CD9-positive bovine epididymosome subpopulation.
"P25b, GliPr1L1, and MIF were highly expressed in CD9-positive microvesicles"
GLIPR1L1 is an IZUMO-binding protein required for optimal fertilization in the mouse.
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Mouse GLIPR1L1 and IZUMO1 form maturation-dependent sperm protein complexes.
"Collectively, these results confirm that IZUMO1 and GLIPR1L1 form a protein complex within male germ cells"
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Mouse GLIPR1L1 promotes acrosome reaction and IZUMO1 redistribution.
"Collectively, these data reveal that GLIPR1L1 has a role in optimizing acrosome function, the translocation of IZUMO1 during the acrosome reaction, and the fertilization process"
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Mouse Glipr1l1 loss reduces in-vitro fertilization after normal zona binding.
"the loss of Glipr1l1 did not affect the ability of sperm to bind to the zona pellucida, but did significantly reduced their ability to fertilize oocytes"
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Mouse Glipr1l1 is not essential for natural male fertility.
"Glipr1l1 knockout males sired litters of equivalent size to that of WT control males"
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The precise biochemical activity remains unresolved.
"While the precise molecular function of GLIPR1L1 therefore remains to be established"
Mouse genome engineering uncovers 18 genes dispensable for male reproduction.
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GLIPR1L1-family genes are highly expressed in mouse and human male reproductive tissues.
"Glipr1l1, Glipr1l2, Izumo4, Slc22a16, Spmip2, Tex51, Tmco2, Triml1, and Triml2 are highly expressed in mouse and human testis and epididymis"
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Deleting all three neighboring mouse Glipr1-like genes does not significantly affect natural male fertility.
"depletion of all three genes does not significantly affect male fertility"
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Triple-knockout males showed normal reproductive histology, sperm morphology, and motility.
"Glipr1l1‐3 KO males exhibited no anomalies in their testis weight, testis and epididymis histology, or sperm morphology and motility"
UniProt entry for human GLIPR1L1 (Q6UWM5)
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Human GLIPR1L1 is highly expressed in testis.
"Highly expressed in testis"
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The mature human protein has an experimentally supported signal-peptide cleavage site.
"SIGNAL 1..22"
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UniProt predicts a C-terminal GPI anchor.
"GPI-anchor amidated glycine"
Manual literature synthesis for human GLIPR1L1