Cul1 (Cullin-1, lin-19) review notes

Accession: Q24311. Planned FlyBase gene-group module (not yet committed to modules/ on main): dmel_scf_slimb_ubiquitin_ligase (Cul1-Roc1a catalytic core).

Literature journal

• SCF assembly: PMID:11500045
• Roc1a binds Cul1-4: PMID:18698375.
• Neddylation and substrates: PMID:12231629; CSN deneddylates Cul1 in oogenesis PMID:12737805.
• K11 chains on Ci: PMID:23747190
• Nutcracker SCF in spermatid caspase activation: PMID:20392747
• Pruning via InR/TOR PMID:24068890; SCA3 polyQ solubility PMID:30685895.

Decisions

• Core MF GO:0160072 ubiquitin ligase complex scaffold activity (own), contributes_to GO:0061630 ubiquitin protein ligase activity; GO:0019005. Same pattern as SkpA, Cul2, EloB, EloC.
• Protein binding: SkpA and Rca1 partner rows MODIFY to GO:0160072; Minus row REMOVE.
• GO:0031461 CRL complex and GO:0006511/GO:0030163/GO:0016567 generic parents non-core; regulation-of-catabolism rows non-core; pathway outputs non-core for the shared scaffold.
• Cytoplasm EXP (PMID:20392747) accepted without quote (no explicit Cul1 localization sentence found in the cached full text).

Revision (batch rule change)

Correct-but-general terms are now MODIFY: GO:0016567 -> GO:0000209; GO:0006511 and GO:0030163 -> GO:0031146; GO:0031461 -> GO:0019005. Supersedes the generic-parent convention above. Positive-regulation-of-catabolism rows remain KEEP_AS_NON_CORE (a peripheral regulatory framing, not a less-specific parent).

Deep research (falcon, added after the initial review)

The falcon deep-research run finished after the initial commit and is now in Cul1-deep-research-falcon.md. Its synthesis is consistent with the annotation decisions above; no review actions were changed.