Gene Ontology annotation through association of InterPro records with GO terms
Electronic Gene Ontology annotations created by ARBA machine learning models
UniProt record for KCTD18 (Q6PI47)
Deep research on KCTD18 including Balasco et al. 2024 comprehensive analysis of KCTD-Cullin 3 structural recognition
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KCTD18 BTB domain is predicted to form a stable 1:1 complex with CUL3
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KCTD18 is predicted to be monomeric, unlike pentameric KCTD family members
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No experimentally validated substrates for KCTD18 have been reported
Cyberian deep research on KCTD18 function
KCTD18 curation notes
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KCTD18 should not receive automatic Cul3 substrate-receptor molecular-function propagation until direct CUL3 binding and substrate-adaptor activity are experimentally supported.
"Curation conclusion: keep KCTD18 in the PN taxonomy as a possible/provisional Cul3-related KCTD-family member, but exclude it from automatic propagation to `GO:1990756` until direct CUL3 binding and substrate-adaptor activity are experimentally supported."
OpenScientist report on KCTD18 CUL3 substrate-adaptor activity
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High-throughput AP-MS/TAP-MS data are consistent with possible KCTD18 CUL3-complex association, but no direct CUL3-binding, substrate, or ubiquitination assay establishes KCTD18 as a CRL3 substrate adaptor.
"While high-throughput proteomics data suggest KCTD18 may associate with CUL3 and CRL complex components, no targeted binding validation, substrate identification, or ubiquitination assay has been published."
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BTB-domain features make CUL3 binding plausible but do not settle the claim, because similar motifs are compatible with both CUL3-binding and nonbinding KCTD proteins.
"However, BTB domain presence with LNVGG motif is **necessary but not sufficient** for CUL3 binding"