Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database

Combined Automated Annotation using Multiple IEA Methods

Cloning and characterization of a novel zinc finger transcriptional repressor. A direct role of the zinc finger motif in repression.

SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex.

AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2.

JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells.

Functional analysis of AEBP2, a PRC2 Polycomb protein, reveals a Trithorax phenotype in embryonic development and in ESCs.

Structures of human PRC2 with its cofactors AEBP2 and JARID2.

Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding.

Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2.

JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications.

Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction.

Auto-inhibition of PRC2 by the broadly expressed long isoform of AEBP2.

Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells.

Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.

Aebp2 as an epigenetic regulator for neural crest cells.

EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells.

A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin.

EZHIP/CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma.

Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin

PRC2 trimethylates histone H3 at lysine-27

PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27)

AEBP2 provenance analysis of the GO annotation set (computed)

Affinage mechanistic annotation for AEBP2 (human)