Fas (rat) review notes

Session 1

• Fetched with just fetch-gene rat Fas; UniProt Q63199 (TNR6_RAT), 134 GOA rows.
• Cached all GOA PMIDs plus PMID:16987298 (requested as a key paper). On reading, PMID:16987298
  is a glioblastoma pharmacology paper; for rat it only shows Fas protein induction in RG2
  glioma cells by n-butylidenephthalide PMID:16987298.
  Recorded as a low-relevance reference; no annotation rests on it.
• No deep-research API; literature synthesis in Fas-deep-research-manual.md.

Decisions

• MF: all GO:0005031 (TNF receptor activity) and GO:0004888 rows MODIFY to GO:0005035 death
  receptor activity (Fas binds FASLG, not TNF), matching the human FAS review.
• Apoptotic BP rows (apoptotic process, apoptotic signaling pathway, extrinsic apoptotic
  signaling pathway) MODIFY to GO:0008625; generic signal transduction and the
  TNF-mediated signaling IEA MODIFY to GO:0036337 Fas signaling pathway.
• death-inducing signaling complex MODIFY to CD95 death-inducing signaling complex.
• IEP rows: KEEP_AS_NON_CORE where the same paper also shows Fas mediates the response
  (blocking antibody, ligand sensitisation); MARK_AS_OVER_ANNOTATED where only expression
  changed. None removed, because IEP response-to terms are formally allowed.
• PMID:29970988: full text read; only Faslg was perturbed. Schwann-cell IMP rows REMOVEd
  with a source defect (wrong gene) - flagged for expert check.
• No NEW terms proposed.