Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database

Combined Automated Annotation using Multiple IEA Methods

Molecular cloning of cDNA encoding a novel microphthalmia-associated transcription factor isoform with a distinct amino-terminus.

Involvement of microphthalmia-associated transcription factor (MITF) in expression of human melanocortin-1 receptor (MC1R).

STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression.

Sumoylation of MITF and its related family members TFE3 and TFEB.

MITF mediates cAMP-induced protein kinase C-beta expression in human melanocytes.

Microphthalmia-associated transcription factor interactions with 14-3-3 modulate differentiation of committed myeloid precursors.

Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor.

SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium.

Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization.

Regulation of MITF stability by the USP13 deubiquitinase.

HERC2 rs12913832 modulates human pigmentation by attenuating chromatin-loop formation between a long-range enhancer and the OCA2 promoter.

Microphthalmia-associated transcription factor (MITF) promotes differentiation of human retinal pigment epithelium (RPE) by regulating microRNAs-204/211 expression.

Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes.

Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression.

Biallelic Mutations in MITF Cause Coloboma, Osteopetrosis, Microphthalmia, Macrocephaly, Albinism, and Deafness.

Melanocytes Sense Blue Light and Regulate Pigmentation through Opsin-3.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

A central role for regulated protein stability in the control of TFE3 and MITF by nutrients.

Functional analysis of microphthalmia-associated transcription factor in pigment cell-specific transcription of the human tyrosinase family genes.

Identification of a novel isoform of microphthalmia-associated transcription factor that is enriched in retinal pigment epithelium.

PIAS3 SUMOylates MITF with SUMO1

MITF gene expression

LEF1, CTNNB1 and MITF-M bind the MITF promoter

MAPK1-dependent phosphorylation of MITF-M

XPO1 binds p-S69,73 MITF-M

XPO1-dependent export of p-S69,S73 MITF-M

RPS6KA1-dependent phosphorylation of MITF-M

GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405

GSK3B phosphorylates p-S73 MITF-M at residue S69

HINT1 binds MITF-M

HINT1, SIN3A and HDAC1 bind MITF-M at the BCL2 promoter

MITF-M dimer binds the BCL2 promoter

p-S207 KARS1 dimer binds MITF-M:HINT1 dimer

p-S207 KARS displaces HINT1

p-S207 KARS1 dimer synthesizes A(5')p4(5')A

MITF-M dimer binds the CDKN1A promoter

MITF-M dimer binds the MET promoter

MITF-M dimer binds an intronic element in the PMEL gene

MITF-M dimer binds MLANA gene

MITF-M dimer binds the TBX2 gene

MITF-M dimer and the SWI/SNF complex bind the TYRP1 promoter

MITF-M dimer, SOX10, pS133 CREB1 and CTNNB1:LEF1 bind the DCT promoter

MITF-M dimer binds the PPARGC1A promoter

MITF-M dimer binds SIRT1 promoter

MITF-M dimer binds GPR143 promoter

MITF-M dimer binds the CEACAM1 gene

MITF-M dimer binds MYO5A gene

MITF-M dimer binds RAB27A gene

MITF-M dimer binds the BIRC7 promoter

MITF-M dimer binds DIAPH1 gene

MITF-M dimer binds GMPR gene

MITF-M dimer binds the TRPM1 gene

MITF-M dimer binds the MIR211 promoter

MITF-M dimer binds the DICER1 gene

MITF-M dimer binds the BCL2A1 gene

MITF-M dimer binds the CDK2 gene

MITF-M dimer binds the PLK1 gene

MITF-M dimer binds the CCNB1 gene

MITF-M dimer binds the CCND1 gene

MITF-M dimer binds the CDKN2A gene

MITF-M dimer binds the LIG1 gene

MITF-M dimer binds the TERT gene

MITF-M binds the promoters of v-ATPase target genes

MITF-M dimer binds the ASAH1 gene

MITF-M dimer and TFAP2A bind intronic elements in the IRF4 gene

MITF-M binds the MCM2 gene

MITF-M binds CDH2 gene

UBE2I sumoylates MITF-M

MITF-M binds GXYLT2 gene

MITF-M binds CREBBP,EP300

MITF-M binds PXN gene

MITF-M binds ITGA2 gene

MARK3 phosphorylates MITF-M on S173

MITF-M binds ZEB1 gene

MITF-M binds EDIL3 gene

MITF-M binds the BRCA1 gene

MITF-M binds the CDC25B gene

MITF-M binds STT3B gene

MITF-M binds SOX2 gene

MITF-M binds PXDN gene

MITF-M binds SERPINE1 gene

MITF-M binds the MCM5 gene

MITF-M binds CDH1 gene

p-S173 MITF-M binds YWHA dimers

UniProt entry O75030 (MITF_HUMAN)

Reviewer notes for human MITF