DNAH11 curation notes

Deep research

Falcon deep research failed twice ("Failed to authenticate"); no deep-research
file. Review based on cached publications, UniProt, and the Europe PMC full text
of PMID:33139725 (PMC7606486), which was read but is cached abstract-only.

Biology summary (with provenance)

• Proximal ODA beta heavy chain PMID:26909801; partial proximal ODA loss by tomography PMID:26909801.
• Hyperkinetic stiff beat, normal ultrastructure [PMID:18022865, PMID:22184204].
• Mouse orthologue lrd: mutated in iv/lgl PMID:9353118; in motile node monocilia
  needed for nodal flow PMID:12859898.
• Situs inversus totalis with DNAH11 nonsense mutation PMID:12142464.
• Not in sperm axoneme PMID:31178125; biallelic nonsense compatible with male
  fertility PMID:18022865.
• CFAP45 co-IPs DNAH11; CFAP45 mislocalized in DNAH11-mutant cilia (full text of
  PMID:33139725).

Annotation decisions

• NEW: outer dynein arm (part_of), since DNAH11 has only the generic dynein
  complex; comparator check: DNAH5, DNAH9 and DNAH17 carry the term.
• Regulation of cilium beat frequency IMPs modified to epithelial cilium movement
  involved in extracellular fluid movement (GO:0003351): the hyperkinetic beat is a
  loss-of-function phenotype of the motor, not a regulatory activity, and DNAH11
  has no cilium movement row in GOA.
• Sperm motility IMP (PMID:18492703) marked over-annotated.
• protein localization to motile cilium (CFAP45, IMP) marked over-annotated: CFAP45
  depends on DNAH11 for its axonemal position [PMC7606486 full text "In contrast,
  CFAP45 ciliary localization was abnormal or undetectable in respiratory cilia from
  several genetically distinct DNAH11-mutant subtypes"], which does not make DNAH11
  a participant in protein localization. The cached record is abstract-only, so
  the full-text sentence is recorded as supporting_text_fulltext.
• Light intermediate chain binding (IEA/IBA) removed: the outer dynein arm has no
  light intermediate chain subunit, so the claim is unlikely to be correct.
• microtubule-based process and microtubule-based movement (IEA) set to
  TOO_GENERAL.

PANTHER / IBA check

Human DNAH11 (Q96DT5) and mouse Dnah11 (E9Q7N9) have identical IBA sets (7 terms);
no human-versus-mouse family split. UniProt PANTHER: PTHR45703:SF12.