GPM1 notes (P00950, YKL152C)
- BPG-dependent phosphoglycerate mutase, EC 5.4.2.11 [UniProt:P00950 "Reaction=(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate;"]; His181 general acid/base PMID:1386023.
- Sole PGAM for glycolysis and gluconeogenesis: deletion cannot grow on glucose or on glycerol or ethanol alone PMID:3033435.
- Mostly cytosolic PMID:3332961; minor mitochondrial-surface pool PMID:16962558; recovered in IMS proteome PMID:22984289.
- Pathway flag: YeastCyc also attaches EC 5.4.2.12 (cofactor-independent iPGM) to GPM1; that is incorrect for this dPGM (UniProt gives only EC 5.4.2.11).
Decisions: REMOVE bifid shunt (GLUCFERMEN-PWY mis-mapping); MODIFY obsolete canonical/G6P glycolysis terms -> GO:0006096; MODIFY generic catalytic / intramolecular phosphotransferase -> GO:0004619; mitochondrial/IMS rows KEEP_AS_NON_CORE.