Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Identification of the Pseudomonas aeruginosa glmM gene, encoding phosphoglucosamine mutase.
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PA4749 encodes phosphoglucosamine mutase.
"The product of this gene is here identified as the phosphoglucosamine mutase (GlmM) which catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate"
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It complements an E. coli glmM mutant for peptidoglycan synthesis and growth.
"shown to restore normal peptidoglycan biosynthesis and cell growth of a glmM Escherichia coli mutant strain"
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Purified GlmM has PMM (20%) and PGM (2%) side activities.
"Beside its phosphoglucosamine mutase activity, the P. aeruginosa enzyme is shown to exhibit phosphomannomutase and phosphoglucomutase activities, which represent about 20 and 2% of its GlmM activity, respectively."
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GlmM does not complement an algC mutant for alginate synthesis.
"when plasmid pIT352 was introduced by triparental mating into the algC mutant strain P. aeruginosa 8858, alginate synthesis was not restored"
UniProt entry Q9HV50 (GLMM_PSEAE)