Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Negative control of p53 by Sir2alpha promotes cell survival under stress.
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression.
Multiple tumor suppressor pathways negatively regulate telomerase.
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.
FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1).
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma.
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity.
Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin.
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.
Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation.
Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation.
Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.
Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage.
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.
SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity.
Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing.
Phosphorylation of HuR by Chk2 regulates SIRT1 expression.
SIRT1 promotes DNA repair activity and deacetylation of Ku70.
Sirtuin functions in health and disease.
Sirtuin 1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen receptor.
SIRT1 regulates the function of the Nijmegen breakage syndrome protein.
Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription.
The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation.
Sirt1 modulates premature senescence-like phenotype in human endothelial cells.
SIRT1 deacetylates and positively regulates the nuclear receptor LXR.
Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity.
SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation.
Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation.
DBC1 is a negative regulator of SIRT1.
Negative regulation of the deacetylase SIRT1 by DBC1.
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.
Epigenetic control of rDNA loci in response to intracellular energy status.
SIRT1 regulates circadian clock gene expression through PER2 deacetylation.
SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation.
Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells.
hSirT1-dependent regulation of the PCAF-E2F1-p73 apoptotic pathway in response to DNA damage.
Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2.
Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins.
Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters.
CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage.
Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor gamma transactivation.
SIRT1 deacetylates APE1 and regulates cellular base excision repair.
Reciprocal roles of SIRT1 and SKIP in the regulation of RAR activity: implication in the retinoic acid-induced neuronal differentiation of P19 cells.
JNK1 phosphorylates SIRT1 and promotes its enzymatic activity.
Repression of estrogen receptor beta function by putative tumor suppressor DBC1.
Role of SIRT1 in homologous recombination.
SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60.
DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.
SIRT1 negatively regulates the mammalian target of rapamycin.
SIRT1 promotes proliferation and prevents senescence through targeting LKB1 in primary porcine aortic endothelial cells.
Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation.
MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1.
SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling.
Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha.
SIRT1 is regulated by a PPAR{γ}-SIRT1 negative feedback loop associated with senescence.
SIRT1 regulates UV-induced DNA repair through deacetylating XPA.
SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism.
Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation.
HDAC3 is negatively regulated by the nuclear protein DBC1.
SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310.
Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C.
MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation.
Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1.
Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1).
Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1.
EVI1 up-regulates the stress responsive gene SIRT1 which triggers deacetylation and degradation of EVI1.
SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability.
The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy.
Sirt1 deacetylates c-Myc and promotes c-Myc/Max association.
Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation.
SIRT1 links CIITA deacetylation to MHC II activation.
The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO.
SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities.
p53 deacetylation by SIRT1 decreases during protein kinase CKII downregulation-mediated cellular senescence.
Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands.
SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive.
Global landscape of HIV-human protein complexes.
Novel repressor regulates insulin sensitivity through interaction with Foxo1.
Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ.
Autoacetylation of the MYST lysine acetyltransferase MOF protein.
Dynamic distribution of linker histone H1.5 in cellular differentiation.
Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1.
The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.
A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.
MicroRNA-mediated epigenetic silencing of sirtuin1 contributes to impaired angiogenic responses.
SIRT4 represses peroxisome proliferator-activated receptor α activity to suppress hepatic fat oxidation.
Antidicer RNAse activity of monocyte chemotactic protein-induced protein-1 is critical for inducing angiogenesis.
AROS has a context-dependent effect on SIRT1.
MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm.
Vascular importance of the miR-212/132 cluster.
CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase.
NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1.
Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription.
Architecture of the human interactome defines protein communities and disease networks.
A Recurrent De Novo PACS2 Heterozygous Missense Variant Causes Neonatal-Onset Developmental Epileptic Encephalopathy, Facial Dysmorphism, and Cerebellar Dysgenesis.
A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity.
Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate.
Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions.
Dynamic acetylation of the kinetochore-associated protein HEC1 ensures accurate microtubule-kinetochore attachment.
The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification.
CCDC84 Acetylation Oscillation Regulates Centrosome Duplication by Modulating HsSAS-6 Degradation.
Acetylation of XPF by TIP60 facilitates XPF-ERCC1 complex assembly and activation.
Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice.
CSAG2 is a cancer-specific activator of SIRT1.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer.
Regulation of HSF1-mediated heat shock response
SIRT1 negatively regulates rRNA expression
eNoSC deacetylates histone H3
eNoSC dimethylates histone H3 at lysine-9
Formation of energy-dependent Nucleolar Silencing Complex (eNoSC)
SIRT1,SIRT3 deacetylate FOXO3
ZEB1 recruits MPHOSPH8 (MPP8) to CDH1 gene promoter
SIRT1 deacetylates HINT1 dimer
MITF-M-dependent SIRT1 gene expression
Deep research report on SIRT1