Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity.
Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs.
Mechanisms governing subcellular localization and function of human RGS2.
Expression of regulator of G protein signaling-2 in rat myometrium during pregnancy and parturition.
Identification of differentially expressed genes in mouse spermatogenesis.
Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure.
Selective loss of fine tuning of Gq/11 signaling by RGS2 protein exacerbates cardiomyocyte hypertrophy.
RGS2 promotes formation of neurites by stimulating microtubule polymerization.
Spinophilin/neurabin reciprocally regulate signaling intensity by G protein-coupled receptors.
Alternative translation initiation of human regulators of G-protein signaling-2 yields a set of functionally distinct proteins.
Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice.
Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2).
Translational control by RGS2.
RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling.
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RGS2 also terminates beta2-adrenergic Gi signaling in a defined cardiac/cellular context.
"RGS2
ablation, similar to βAR agonist stimulation, sustains the β(2)AR-G(i) signaling"
RGS2 and RGS4 modulate melatonin-induced potentiation of glycine currents in rat retinal ganglion cells.
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The donor study measures glycine-evoked currents, which do not establish glycine import.
"using immunohistochemistry, Western
blot analysis and whole-cell patch-clamp techniques"
A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity.
A proteome-scale map of the human interactome network.
Widespread macromolecular interaction perturbations in human genetic disorders.
The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration.
Chronic intermittent ethanol exposure selectively alters the expression of Gα subunit isoforms and RGS subtypes in rat prefrontal cortex.
Human Missense Mutations in Regulator of G Protein Signaling 2 Affect the Protein Function Through Multiple Mechanisms.
Regulator of G Protein Signaling 2 Facilitates Uterine Artery Adaptation During Pregnancy in Mice.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
GPCR downstream signalling
Active G alpha (q) binds RGS proteins
G alpha (q) in G (q):RGS complex is inactivated
G alpha (q):RGS dissociates to inactive G alpha (q)