Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Arginine/lysine-rich structural element is involved in interferon-induced nuclear import of STATs.
Affinity of Stat2 for the subunits of the interferon alpha receptor.
Hepatitis C virus expression suppresses interferon signaling by degrading STAT1.
Simian virus 5 V protein acts as an adaptor, linking DDB1 to STAT2, to facilitate the ubiquitination of STAT1.
Acetylation-dependent signal transduction for type I interferon receptor.
STAT2 is a primary target for measles virus V protein-mediated alpha/beta interferon signaling inhibition.
Divergent susceptibilities of human herpesvirus 6 variants to type I interferons.
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
Identification of STAT2 serine 287 as a novel regulatory phosphorylation site in type I interferon-induced cellular responses.
STAT2 deficiency and susceptibility to viral illness in humans.
STAT heterodimers in immunity: A mixed message or a unique signal?
IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage.
Signal transducer and activator of transcription 2 deficiency is a novel disorder of mitochondrial fission.
PIPINO: A Software Package to Facilitate the Identification of Protein-Protein Interactions from Affinity Purification Mass Spectrometry Data.
Global functional profiling of human ubiquitome identifies E3 ubiquitin ligase DCST1 as a novel negative regulator of Type-I interferon signaling.
STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling.
Architecture of the human interactome defines protein communities and disease networks.
Histone deacetylase 4 promotes type I interferon signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6.
Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in STAT2.
Homozygous STAT2 gain-of-function mutation by loss of USP18 activity in a patient with type I interferonopathy.
SARS-CoV-2 N protein antagonizes type I interferon signaling by suppressing phosphorylation and nuclear translocation of STAT1 and STAT2.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response.
Unresolvable identifier - no record in NCBI PubMed (likely a GOA data error)
Human transcription factor protein interaction networks.
Multimodal cell maps as a foundation for structural and functional genomics.
Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein.
The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals.
Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA.
Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling.
Identification of amino acid residues critical for the Src-homology 2 domain-dependent docking of Stat2 to the interferon alpha receptor.
ISGF3 binds the ISRE promoter elements in IFN-stimulated genes
IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5
p-STAT1, p-Y-STAT2, p-STAT3, p-STAT4, p-STAT5 dissociates from IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:p-STAT1,p-STAT2,p-STAT3,p-STAT4,p-STAT5
IFNL1:p-Y434,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2 binds STAT1, STAT2, STAT3, STAT4, STAT5
Formation of p-STAT1 homodimer
Recruitment of STAT2 to p-IFNAR1
IFN alpha/beta binds to IFNAR2
Translocation of ISGF3 complex to nucleus
Release of p-STAT2:p-STAT1 dimer
Interaction of IRF9 with p-STAT2:p-STAT1
Activation of JAK kinases
Phosphorylation of INFAR1 by TYK2
IFNAR2:JAK1:STAT2 binds JAK1,2 inhibitors
IFNAR2:JAK1:STAT2 binds type 1 interferon analogs
p-STAT1 dimer binds KPNA1
p-STAT1dimer:KPNA1 binds KPNB1
SARS-CoV-2 N protein binds STAT1, STAT2
Dephosphorylation of STAT1 by SHP2
Dephosphorylation of TYK2 by PTP1B
Dephosphorylation of JAK1 by SHP1