Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones.
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Foundational paper establishing the mitochondrial unfolded protein response (UPR-mt) in C. elegans
"These observations support the existence of a mitochondrial unfolded protein response that couples mitochondrial chaperone gene expression to changes in the protein handling environment in the organelle."
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Demonstrated hsp-6 is specifically induced by mitochondrial protein folding stress
"hsp-6 and hsp-60 induction was specific to perturbed mitochondrial protein handling, as neither heat-shock nor endoplasmic reticulum stress nor manipulations that impair mitochondrial steps in intermediary metabolism or ATP synthesis activated the mitochondrial chaperone genes."
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Established hsp-6 and hsp-60 as mitochondrial matrix chaperone genes
"We found that the mitochondrial matrix HSP70 and HSP60 chaperones, encoded by the Caenorhabditis elegans hsp-6 and hsp-60 genes, were selectively activated by perturbations that impair assembly of multi-subunit mitochondrial complexes"
Knockdown of mitochondrial heat shock protein 70 promotes progeria-like phenotypes in caenorhabditis elegans.
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Established HSP-6 as the C. elegans mtHSP70 ortholog with import motor function
"Mitochondrial heat shock protein 70 (mthsp70) functions as a mitochondrial import motor and is essential in mitochondrial biogenesis and energy generation in eukaryotic cells. HSP-6 (hsp70F) is a nematode orthologue of mthsp70."
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Demonstrated HSP-6 is essential for mitochondrial biogenesis
"Knockdown of HSP-6 by RNA interference in young adult nematodes caused a reduction in the levels of ATP-2, HSP-60 and CLK-1, leading to abnormal mitochondrial morphology and lower ATP levels."
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Linked HSP-6 reduction to progeria-like phenotypes and shortened lifespan
"RNA interference-treated worms had lower motility, defects in oogenesis, earlier accumulation of autofluorescent material, and a shorter life span."
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Showed HSP-6 levels decline at end of lifespan
"The amount of HSP-6 became dramatically reduced at the expected mean life span in not only wild-type but also in long and short life span mutant worms (wild-type, daf-2, and daf-16)."
Deep research synthesis on C. elegans hsp-6 (HSP-6/mtHSP70)
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HSP-6 is the C. elegans mitochondrial HSP70 chaperone central to mitochondrial proteostasis
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hsp-6p::GFP is a validated ATFS-1-dependent reporter of UPR-mt activation
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HSP-6 functions as an ATP-dependent chaperone supporting protein import and folding