Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of intracellular localizations of expressed fusion proteins in living cells
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Plasma cell differentiation requires the transcription factor XBP-1.
pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response.
Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1.
Human X-box-binding protein 1 is required for the transcription of a subset of human class II major histocompatibility genes and forms a heterodimer with c-fos.
Protective effect against Parkinson's disease-related insults through the activation of XBP1.
Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA.
Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays.
A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response.
Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation.
Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain.
The unfolded protein response: integrating stress signals through the stress sensor IRE1α.
The endoplasmic reticulum stress response in aging and age-related diseases.
Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis.
Networks of bZIP protein-protein interactions diversified over a billion years of evolution.
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway.
Unspliced X-box-binding protein 1 (XBP1) protects endothelial cells from oxidative stress through interaction with histone deacetylase 3.
Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u.
MicroRNA-214 Is Upregulated in Heart Failure Patients and Suppresses XBP1-Mediated Endothelial Cells Angiogenesis.
Impact of cytosine methylation on DNA binding specificities of human transcription factors.
BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress.
Sledgehammer to Scalpel: Broad Challenges to the Heart and Other Tissues Yield Specific Cellular Responses via Transcriptional Regulation of the ER-Stress Master Regulator ATF6α.
A reference map of the human binary protein interactome.
The basic domain/leucine zipper protein hXBP-1 preferentially binds to and transactivates CRE-like sequences containing an ACGT core.
XBP(S) mRNA is translated and XBP1(S) translocates to the nucleus
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.