Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans.
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AAK-2 is the C. elegans AMPK alpha subunit activated by AMP
"The C. elegans AMP-activated protein kinase alpha subunit AAK-2 is activated by AMP"
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Functions as energy sensor linking AMP:ATP ratio to lifespan
"The AMP:ATP ratio, a measure of energy levels, increases with age in Caenorhabditis elegans and can be used to predict life expectancy"
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Required for lifespan extension under reduced insulin signaling
"AAK-2 is a sensor that couples lifespan to information about energy levels and insulin-like signals"
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Involved in dauer development regulation
"AAK-2 is a sensor that couples lifespan to information about energy levels and insulin-like signals"
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Phosphorylated at Thr-243 for activation
"The C. elegans AMP-activated protein kinase alpha subunit AAK-2 is activated by AMP"
The Caenorhabditis elegans AMP-activated protein kinase AAK-2 is phosphorylated by LKB1 and is required for resistance to oxidative stress and for normal motility and foraging behavior.
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AAK-2 is phosphorylated at Thr-243 by PAR-4 (LKB1 homolog)
"AAK-2 was phosphorylated at threonine 243 in response to paraquat treatment and that this phosphorylation depends on PAR-4"
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Required for resistance to oxidative stress (paraquat)
"Both aak-2 mutation and par-4 knockdown increased the sensitivity of C. elegans worms to paraquat"
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Required for normal locomotion and foraging behavior
"Both mutations also slowed body bending during locomotion and failed to reduce head oscillation in response to anterior touch"
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Expressed in ventral cord, neurons, body wall muscle, pharynx, vulva, somatic gonad
"expression of the AAK-2::green fluorescent protein fusion protein was observed in the ventral cord, some neurons, body wall muscle, pharynx, vulva, somatic gonad, and excretory cell"
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GFP localization studies show cytoplasmic, axonal, and neuronal localization
"expression of the AAK-2::green fluorescent protein fusion protein was observed in the ventral cord, some neurons"
Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network.
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High-throughput yeast two-hybrid study identifying protein interactions
"We present an expanded C. elegans protein-protein interaction network, or 'interactome' map"
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AAK-2 interacts with AAKB-2 (AMPK beta subunit)
"We present an expanded C. elegans protein-protein interaction network"
AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans.
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Serotonin signaling modulates feeding through AMPK inhibition in interneurons
"neural serotonin signaling in C. elegans modulates feeding behavior through inhibition of AMP-activated kinase (AMPK) in interneurons"
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AAK-2/AMPK regulates glutamate release from interneurons
"glutamatergic signaling links these interneurons to pharyngeal neurons implicated in feeding behavior"
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Links serotonergic signaling to pharyngeal pumping/feeding behavior
"AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior"
A tachykinin-like neuroendocrine signalling axis couples central serotonin action and nutrient sensing with peripheral lipid metabolism.
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AAK-2/AMPK in ASI neurons regulates FLP-7 neuropeptide secretion
"loss of aak-2, the C. elegans orthologue of the AMP kinase alpha subunit (AMPK) led to a reduction in body fat stores"
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AMPK phosphorylates CRTC-1 to keep it inactive, restraining FLP-7 secretion
"in wild-type ASI neurons, AMPK signalling serves to keep the CREB co-regulator CRTC-1 inactive, which in turn restrains FLP-7 secretion"
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Loss of aak-2 leads to increased FLP-7 secretion and fat loss
"loss of aak-2, the C. elegans orthologue of the AMP kinase alpha subunit (AMPK) led to a reduction in body fat stores"
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Links nutrient sensing to peripheral fat metabolism
"FLP-7 is secreted as a neuroendocrine peptide in proportion to fluctuations in neural serotonin circuit functions, and its release is regulated from secretory neurons via the nutrient sensor AMPK"
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aak-2 mutants have approximately 60% reduction in body fat
"loss of aak-2, the C. elegans orthologue of the AMP kinase alpha subunit (AMPK) led to a reduction in body fat stores, to approximately the same extent as 5-HT treatment"
High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in Caenorhabditis elegans.
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AAK-2/AMPK activity mitigates high glucose toxicity
"mitigated by AMP-activated protein kinase in Caenorhabditis elegans"
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AICAR treatment activates AMPK and reduces negative effects of high glucose
"AICAR treatment also reduced the negative effects of HG"
Deep research report on aak-2