Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation by the MGI curatorial staff, curated orthology
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Automatic assignment of GO terms using logical inference, based on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Expression characteristics and relevance of sodium glucose cotransporter-1 in mammalian renal tubulogenesis.
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SGLT1 is expressed during renal tubulogenesis with developmental regulation
"A high mRNA and protein expression of SGLT-1 was seen in tubular segments of the inner cortex and outer medulla at day 16, and it was developmentally regulated"
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Antisense knockdown selectively decreases tubule population in metanephric explants
"Treatment with SGLT-1 antisense selectively decreased the population of tubules in the metanephric explants"
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SGLT1 activity (14C-glucose uptake) increases during gestation in tubular segments
"uptake, increased during gestation in the tubular segments where it is expressed"
Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity.
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SGLT1 protein upregulated 7-fold in RS1-/- mouse intestine
"In the small intestines of RS1(-/-) mice, the SGLT1 protein was up-regulated sevenfold compared to that of wild-type mice"
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SGLT1 localized to brush border membrane
"In the small intestines of RS1(-/-) mice, the SGLT1 protein was up-regulated sevenfold compared to that of wild-type mice but was not changed in the kidneys"
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Increased intestinal glucose absorption leads to obesity phenotype
"Small intestinal d-glucose uptake measured in jointly perfused small bowel and liver was increased twofold compared to that of the wild-type"
Antibodies to a renal Na+/glucose cotransport system localize to the apical plasma membrane domain of polar mouse embryo blastomeres.
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SGLT1 epitopes localize to apical plasma membrane in 16-cell blastomeres
"by the 16-cell stage epitope expression appeared to become restricted to FS Con A-labeled apical plasma membrane domains and was no longer evident on basolateral domains"
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Expression begins after second cleavage
"IIF did not detect these epitopes until after the second cleavage when 4-cell embryos expressed low-to-moderate levels"
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Apical restriction confirmed by immunogold labeling
"This apparent apical restriction of epitope expression was confirmed by electron microscopic examination of immunogold-labeled isolated polar 16-cell blastomeres"
Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion.
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SGLT1-/- mice develop glucose-galactose malabsorption syndrome and die on standard diet
"Removal of SGLT1 in mice resulted in GGM syndrome (OMIM 182380) that could be cured by a glucose-galactose–reduced diet"
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SGLT1 mediates >80% of intestinal glucose uptake across BBM
"Without and with d-glucose load the capacity of SGLT1 versus GLUT2 for d-glucose transport across the BBMs was 5.5 and 8.7 times higher, respectively"
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SGLT1 triggers glucose-induced GIP and GLP-1 secretion
"Using the SGLT1−/− mice we now demonstrate the pivotal role of SGLT1 for both GLP-1 and GIP secretory responses triggered by oral glucose in vivo"
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SGLT1 reabsorbs approximately 3% of filtered glucose in kidney S3 segment
"Sglt1−/− mice lose ∼3% of the filtered glucose in the urine"
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SGLT1 required for GLUT2 upregulation at BBM
"this translocation of GLUT2 was not observed in Sglt1−/− mice, indicating that SGLT1 rather than sweet taste receptors is pivotal in this upregulation"
Deep research report on Slc5a1