Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs by Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Genetic and structural characterization of the human mitochondrial inner membrane translocase.
Methylation-controlled J-protein MCJ acts in the import of proteins into human mitochondria.
-
MCJ is anchored in the mitochondrial inner membrane with its C-terminal J domain facing the matrix; it forms a subcomplex with MAGMAS/PAM16, interacts with the core TIM23 translocase, and its soluble J domain stimulates the ATPase activity of mortalin (HSPA9), an activity counteracted by MAGMAS; MCJ loss impairs pre-protein import.
MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations.
-
MCJ impairs the formation of respiratory supercomplexes and functions as a negative regulator of the respiratory chain; MCJ loss increases complex I activity, mitochondrial membrane potential, and ATP production.
A proteome-scale map of the human interactome network.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
UniProt entry Q9Y5T4 (DJC15_HUMAN), DnaJ homolog subfamily C member 15 / MCJ