Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
A diverse range of gene products are effectors of the type I interferon antiviral response.
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.
Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity.
Structural mechanism of cytosolic DNA sensing by cGAS.
Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses.
Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.
Structure-guided reprogramming of human cGAS dinucleotide linkage specificity.
PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1.
Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
The N terminus of cGAS de-oligomerizes the cGAS:DNA complex and lifts the DNA size restriction of core-cGAS activity.
Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation.
cGAS surveillance of micronuclei links genome instability to innate immunity.
Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.
Human Cytomegalovirus Tegument Protein pp65 (pUL83) Dampens Type I Interferon Production by Inactivating the DNA Sensor cGAS without Affecting STING.
TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing.
Human Cytomegalovirus Protein UL31 Inhibits DNA Sensing of cGAS to Mediate Immune Evasion.
DNA-induced liquid phase condensation of cGAS activates innate immune signaling.
Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance.
ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response.
NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation.
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis.
G3BP1 promotes DNA binding and activation of cGAS.
Acetylation Blocks cGAS Activity and Inhibits Self-DNA-Induced Autoimmunity.
The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus.
Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA.
Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation.
The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death.
Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death.
Tight nuclear tethering of cGAS is essential for preventing autoreactivity.
Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis.
BAF restricts cGAS on nuclear DNA to prevent innate immune activation.
Mn(2+) Directly Activates cGAS and Structural Analysis Suggests Mn(2+) Induces a Noncanonical Catalytic Synthesis of 2'3'-cGAMP.
KAT5 acetylates cGAS to promote innate immune response to DNA virus.
Structural mechanism of cGAS inhibition by the nucleosome.
Structural basis for the inhibition of cGAS by nucleosomes.
Structural basis for nucleosome-mediated inhibition of cGAS activity.
cGAS-mediated induction of type I interferon due to inborn errors of histone pre-mRNA processing.
A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA.
ER-directed TREX1 limits cGAS activation at micronuclei.
Phosphorylation and chromatin tethering prevent cGAS activation during mitosis.
Arginine methyltransferase PRMT5 negatively regulates cGAS-mediated antiviral immune response.
Translation stress and collided ribosomes are co-activators of cGAS.
PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation.
ZDHHC18 negatively regulates cGAS-mediated innate immunity through palmitoylation.
Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS.
MicroRNA-4691-3p inhibits the inflammatory response by targeting STING in human dental pulp cells: A laboratory investigation.
Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy.
The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation.
HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity.
The structural basis for 2'-5'/3'-5'-cGAMP synthesis by cGAS.
AARS1 and AARS2 sense L-lactate to regulate cGAS as global lysine lactyltransferases.
MYO1F positions cGAS on the plasma membrane to ensure full and functional signaling.
STING mediated induction of host immune responses
cGAS produces cyclic GMP-AMP