Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Occurrence of a putative SCF ubiquitin ligase complex in Drosophila.
Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development.
A ubiquitin-proteasome pathway represses the Drosophila immune deficiency signaling cascade.
The COP9 signalosome promotes degradation of Cyclin E during early Drosophila oogenesis.
Molecular dissection of the APC/C inhibitor Rca1 shows a novel F-box-dependent function.
Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation.
Identifying determinants of cullin binding specificity among the three functionally different Drosophila melanogaster Roc proteins via domain swapping.
Drosophila Minus is required for cell proliferation and influences Cyclin E turnover.
Regulation of Drosophila vasa in vivo through paralogous cullin-RING E3 ligase specificity receptors.
A novel F-box protein is required for caspase activation during cellular remodeling in Drosophila.
Drosophila homeodomain-interacting protein kinase inhibits the Skp1-Cul1-F-box E3 ligase complex to dually promote Wingless and Hedgehog signaling.
Defining components of the ß-catenin destruction complex and exploring its regulation and mechanisms of action during development.
Ter94 ATPase complex targets k11-linked ubiquitinated ci to proteasomes for partial degradation.
A novel dRYBP-SCF complex functions to inhibit apoptosis in Drosophila.
A Cullin1-based SCF E3 ubiquitin ligase targets the InR/PI3K/TOR pathway to regulate neuronal pruning.
SCF(Slmb) E3 ligase-mediated degradation of Expanded is inhibited by the Hippo pathway in Drosophila.
Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling.
FipoQ/FBXO33, a Cullin-1-based ubiquitin ligase complex component modulates ubiquitination and solubility of polyglutamine disease protein.
Dual functions of Rack1 in regulating Hedgehog pathway.
SCF-Fbxo42 promotes synaptonemal complex assembly by downregulating PP2A-B56.
Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription.
Dissociation of free ubiquitinated and phosphorylated ARM from SLMB and the 'destruction complex'
SLMB binds to phosphorylated ARM to form the 'destruction complex'
SLMB binds to and ubiquitinates phosphorylated CI
Ubiquitinated and phosphorylated CI is partially degraded by the proteasome complex
The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals.
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Both RNAi knockdown and overexpression of Cul1 cause apical detachment of scolopidia in Johnston's organ, and Ubr3 negatively regulates Cul1 (SCF); SCF is not the direct E3 for MyoII mono-ubiquitination.
"Together, our data show that Ubr3 negatively regulates Cul1 (SCF) E3 ligase, and that both E3 ligases control the mono-ubiquitination of MyoII and apical attachment of scolopidia."