MCTS1 (MCT-1, Malignant T-cell-amplified sequence 1) — research notes

UniProt Q9ULC4. Contains a PUA domain (RNA-binding). Partner of DENR; the MCTS1-DENR heterodimer is the eIF2D-like non-canonical reinitiation/recycling factor (MCTS1 = N-terminal half of Ligatin/eIF2D, DENR = C-terminal SUI1 half).

• PMID:16982740
• PMID:20713520
• PMID:29889857
• PMID:37875108 MCTS1-dependent reinitiation translates JAK2; essential for IFN-γ immunity (IMP from patient cells).
• Originally identified as oncogene amplified in T-cell lymphoma (PMID:11709712, cytoplasmic).

MF decisions

• translation initiation factor activity (GO:0003743, IDA 20713520) — core.
• ribosomal small subunit binding (GO:0043024, IDA 20713520) — core (binds 40S).
• RNA cap binding (GO:0000339, IDA 16982740) — supported by the cap-complex interaction via PUA; KEEP/ACCEPT but note it is in context of cap complex.
• RNA binding (GO:0003723, IEA) — PUA domain; KEEP_AS_NON_CORE.
• protein binding IPI with DENR (O43583) — the obligate partner; KEEP_AS_NON_CORE.
• reinitiation, ribosome disassembly, preinitiation complex formation, IRES init — core/non-core as for DENR.