drkA (Q54H46; rk1, vsk1; DDB_G0289791) notes

Identity and architecture

642 aa; signal peptide 1-23, extracellular 24-322, TM 323-343, cytoplasmic 344-642 with protein kinase domain 374-627 (UniProt features, predicted). ATP loop 380-388, K401, proton acceptor D497. N-glycosylation sites predicted in ectodomain.
TKL group, DRK family receptor kinase PMID:16596165; rk1 and rk2 share a Dictyostelium-specific extracellular domain PMID:16596165.

Candidate STATa kinase identified by homology to tyrosine-selective TKLs (Pyk2/Pyk3 are STATc kinases) PMID:31002205.
Expression almost exclusively in pstA cells PMID:31002205.
Over-expression increases STATa phosphorylation but is toxic PMID:31002205.
Autophosphorylates on Tyr and Thr; phosphorylates STATa Tyr702 in vitro, SH2-dependent PMID:31002205.

Core MF: protein tyrosine kinase activity (IDA). Ser/Thr: Thr autophosphorylation only -> non-core; serine kinase (Rhea) unsupported -> over-annotated.
Cytoplasm IBA: PANTHER node dominated by soluble TKLs; DrkA is a predicted type I TM protein -> over-annotated.
Root CC ND removed (membrane IEA present).
No NEW terms: localization (plasma membrane vs vesicle) not experimentally established; "vsk1"/"vesicle-associated" name has no traceable primary evidence found.

just deep-research-falcon DICDI drkA --fallback perplexity-lite was run (2026-10-05) but produced no output file (falcon and perplexity-lite fallback both yielded nothing; log not retained). Review is based on cached publications (PMID:31002205 abstract, PMID:16596165 full text), UniProt and web search.