SGD gene description for GLR1 (yeast)
Glutathione redox potential in the mitochondrial intermembrane space is linked to the cytosol and impacts the Mia40 redox state.
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IMS and cytosolic glutathione pools are linked via porins, and the cytosolic glutathione reductase system is the major determinant of the IMS glutathione redox potential.
"we find that the cytosolic glutathione reductase system is the major determinant of E(GSH) in the IMS"
Alternative start sites in the Saccharomyces cerevisiae GLR1 gene are responsible for mitochondrial and cytosolic isoforms of glutathione reductase.
Cellular factors required for protection from hyperoxia toxicity in Saccharomyces cerevisiae.
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Mitochondrial Glr1 and Pos5, but not their cytosolic counterparts, are critical for hyperoxia resistance.
"two factors that help maintain mitochondrial GSH in the reduced form, namely the NADH kinase Pos5p and the mitochondrial glutathione reductase (Glr1p), are critical for hyperoxia resistance, whereas their cytosolic counterparts are not"
Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Combined Automated Annotation using Multiple IEA Methods
YeastPathways to GO-CAM conversion
Global analysis of protein localization in budding yeast.
The proteome of Saccharomyces cerevisiae mitochondria.
Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.
Characterization of a novel dithiocarbamate glutathione reductase inhibitor and its use as a tool to modulate intracellular glutathione.
Thioredoxins function as deglutathionylase enzymes in the yeast Saccharomyces cerevisiae.
Multiple glutathione disulfide removal pathways mediate cytosolic redox homeostasis.
N-terminal acetylation by NatC is not a general determinant for substrate subcellular localization in Saccharomyces cerevisiae.
Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae.
Systematic multi-level analysis of an organelle proteome reveals new peroxisomal functions.
Isolation, characterization and overexpression of the yeast gene, GLR1, encoding glutathione reductase.
Stationary-phase induction of GLR1 expression is mediated by the yAP-1 transcriptional regulatory protein in the yeast Saccharomyces cerevisiae.
UniProt entry P41921 (GLR1)