Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Identification of two new mu-adaptin-related proteins, mu-ARP1 and mu-ARP2.
AP-4, a novel protein complex related to clathrin adaptors.
Characterization of a fourth adaptor-related protein complex.
Signal-binding specificity of the mu4 subunit of the adaptor protein complex AP-4.
Functional and physical interactions of the adaptor protein complex AP-4 with ADP-ribosylation factors (ARFs).
AP-4 binds basolateral signals and participates in basolateral sorting in epithelial MDCK cells.
Adaptor protein complex-4 (AP-4) is expressed in the central nervous system neurons and interacts with glutamate receptor delta2.
Accumulation of AMPA receptors in autophagosomes in neuronal axons lacking adaptor protein AP-4.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Mutation in the AP4M1 gene provides a model for neuroaxonal injury in cerebral palsy.
Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex.
A proteome-scale map of the human interactome network.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex.
Association between Rare Variants in AP4E1, a Component of Intracellular Trafficking, and Persistent Stuttering.
AP-4 mediates export of ATG9A from the trans-Golgi network to promote autophagosome formation.
Altered distribution of ATG9A and accumulation of axonal aggregates in neurons from a mouse model of AP-4 deficiency syndrome.
AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A.
Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndrome.
The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A.
A reference map of the human binary protein interactome.
The role of AP-4 in cargo export from the trans-Golgi network and hereditary spastic paraplegia.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Intrathecal AAV9/AP4M1 gene therapy for hereditary spastic paraplegia 50 shows safety and efficacy in preclinical studies.
trans-Golgi Network Vesicle Budding
AP4 transports APP from trans-Golgi network to endosome lumen
UniProtKB O00189 (AP4M1_HUMAN) flat-file record
AP4M1 bioinformatics - cargo-signal site, GOA reconciliation and ARBA rule reproducibility
Affinage mechanistic annotation for AP4M1 (human)