Gene Ontology annotation through association of InterPro records with GO terms
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Electronic Gene Ontology annotations created by ARBA machine learning models
TreeGrafter-generated GO annotations
Combined Automated Annotation using Multiple IEA Methods
Phosphate starvation-independent 2-aminoethylphosphonic acid biodegradation in a newly isolated strain of Pseudomonas putida, NG2.
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PhnWX pathway enzyme activities were measured in NG2, with substrate-dependent induction.
"phosphonoacetaldehyde hydrolase (phosphonatase) activities which were inducible"
2-Aminoethylphosphonate utilization in Pseudomonas putida BIRD-1 is controlled by multiple master regulators.
The crystal structure of bacillus cereus phosphonoacetaldehyde hydrolase: insight into catalysis of phosphorus bond cleavage and catalytic diversification within the HAD enzyme superfamily.
Insights into the mechanism of catalysis by the P-C bond-cleaving enzyme phosphonoacetaldehyde hydrolase derived from gene sequence analysis and mutagenesis.
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Purified Bacillus and Salmonella PhnX enzymes establish phosphonoacetaldehyde hydrolysis and the Schiff-base mechanism.
"the genes encoding phosphonatase in Bacillus cereus and in Salmonella typhimurium were cloned"
UniProtKB entry for PSEPK phnX
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"Reaction=phosphonoacetaldehyde + H2O = acetaldehyde + phosphate + H(+);"
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"FUNCTION: Involved in phosphonate degradation."
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"DR InterPro; IPR006323; Phosphonoacetald_hydro."
OpenScientist deep research report for PSEPK phnX
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"The gene *phnX* (PP_2208; UniProt **Q88KT1**) of *Pseudomonas putida* KT2440 encodes **phosphonoacetaldehyde hydrolase**, commonly called **"phosphonatase"** (EC 3.11.1.1)."
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Provider synthesis places PhnX as the second enzyme of PhnWX, consistent with PMID:9649311 and the UniProt HAMAP annotation; not used as row support.
"in the second step, **PhnX cleaves PAA** to acetaldehyde and phosphat"
The Microbial Degradation of Natural and Anthropogenic Phosphonates.
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Phosphonate catabolism follows transporter-mediated uptake, placing PhnWX chemistry inside the cell.
"the import of phosphonates implies the involvement of transporters"
PTHR43434 family review
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The family review judges the PAINT cytosol IBD at PTN001291474 sound for these soluble, signal-less HAD enzymes.
"Members are small soluble enzymes without signal peptides or membrane anchors, acting on"