GO_REF:0000033

Annotation inferences using phylogenetic trees

SecY annotations are inferred from well-characterized orthologs through phylogenetic analysis

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping

Membrane raft localization inferred from UniProt subcellular location annotation

GO_REF:0000104

Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins

Annotations transferred based on shared sequence features with characterized Sec translocon subunits

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:23651456

Flotillins functionally organize the bacterial membrane

UniProt:P16336

UniProt entry for B. subtilis SecY

SecY is a 431 amino acid multi-pass membrane protein

"SECY_BACSU Reviewed; 431 AA"
Forms heterotrimer with SecE and SecG

"Heterotrimer consisting of SecY, SecE and SecG subunits"
Interacts with SecA, SecDF, and the ribosome

"Interacts with the ribosome. Interacts with SecDF"
Interacts with FloT and localizes to membrane rafts

"Interacts with FloT (PubMed:23651456)"
Member of SecY/SEC61-alpha family

"Belongs to the SecY/SEC61-alpha family"

file:BACSU/secY/secY-deep-research-falcon.md

Deep research review for B. subtilis SecY

SecY is the channel-forming subunit of the SecYEG translocon

"SecY is the channel-forming subunit of the bacterial SecYEG translocon"
SecY conducts preproteins across the cytoplasmic membrane

"conducts preproteins across the cytoplasmic membrane (secretion)"
SecY supports both post-translational and co-translational transport

"co-translational routes can also target substrates to SecYEG via SRP-ribosome interactions"
SecYEG operates with SecA ATPase for post-translational secretion

"Operates as SecYEG with SecA ATPase"
Proton-motive force enhances translocation efficiency in vivo

"the proton-motive force (PMF) accelerates export"