ClpX (CG4538, A0A0B4LID7) notes

2026-10-09 review session (module dmel_mitochondrial_clpxp)

• Deep research falcon: first attempt rate-limited (HTTP 429), rerun pending at review time.
• UniProt entry is an unreviewed isoform record ("Caseinolytic protease chaperone subunit, isoform C").
• Matsushima et al. 2017:
• PMID:28814717
• PMID:28814717
• PMID:28814717

Decisions

• Core: ATP hydrolysis activity, contributing to ATP-dependent peptidase activity of ClpXP, in the
  mitochondrial endopeptidase Clp complex (matrix).
• protein folding / ATP-dependent protein folding chaperone (InterPro IEA): KEEP_AS_NON_CORE. ClpX is
  primarily an unfoldase for ClpP; ClpP-independent chaperone roles are known for yeast/mammalian
  orthologs but untested in flies.