SSR1 PN Consistency Notes

• Generated: 2026-06-18
• Project: PROTEOSTASIS
• Scope: priority-only PN rereview against local AIGR review and available deep-research artifacts
• UniProt: P43307
• AIGR review status: COMPLETE
• Priority category: positive_control
• Local AIGR project status: local_review_complete_not_phase1
• Related project: ER_PHAGY.md

Source Files Checked

• AIGR review YAML: present - genes/human/SSR1/SSR1-ai-review.yaml
• AIGR review HTML: present - genes/human/SSR1/SSR1-ai-review.html
• Gene notes: present - genes/human/SSR1/SSR1-notes.md
• GOA TSV: present - genes/human/SSR1/SSR1-goa.tsv
• UniProt record: present - genes/human/SSR1/SSR1-uniprot.txt
• PROTEOSTASIS priority table: projects/PROTEOSTASIS/priority_genes.tsv
• PN projection report: projects/PROTEOSTASIS/reports/pn_projection/pn_projected_gene_go_summary.tsv
• PN mapping audit: projects/PROTEOSTASIS/reports/pn_mapping_audit/current_mapping_scrutiny.tsv
• PN mapping file: projects/PROTEOSTASIS/mappings/er_proteostasis.yaml

Deep Research Files

• genes/human/SSR1/SSR1-deep-research-falcon.md

AIGR Review Snapshot

• Description: SSR1 encodes Translocon-associated protein subunit alpha (TRAP-alpha), a single-pass type I ER membrane glycoprotein that is a core component of the heterotetrameric TRAP complex (TRAP-alpha/beta/gamma/delta, encoded by SSR1-4). The TRAP complex stably associates with the Sec61 protein-conducting channel and ribosomes at the ER membrane, facilitating co-translational translocation of secretory and membrane proteins, particularly those with weak or atypical signal peptides. TRAP-alpha features a large N-terminal luminal domain positioned beneath the Sec61 channel exit site and a single long transmembrane helix that contacts Sec61. The complex coordinates with the oligosaccharyltransferase (OST) to couple translocation with N-glycosylation. TRAP-alpha also participates in ER quality control and ERAD pathways.
• Existing/core annotation action counts: ACCEPT: 8; KEEP_AS_NON_CORE: 1; MARK_AS_OVER_ANNOTATED: 1; MODIFY: 5; NEW: 1

PN Consistency Summary

• Consistency: Priority-only record; no phase-1 dossier section exists yet. Local review status is local_review_complete_not_phase1. PN placement: ER proteostasis > Protein transport > TRAP complex component. Main issue: Good example where PN context is compatible with existing ER targeting/translocation GO terms
• PN story / NEW pressure: Current projection rows: GO:0015031 protein transport (entailed_by_goa_closure).
• Mapping strategy: Use as a calibration case for PN-to-GO propagation: the PN placement should agree with an already well-supported local review rather than driving broad new ontology pressure.
• Verdict: Add to boundary/phase1 tracking as a mapping positive control

Priority Review Context

• Category: positive_control
• PN annotations: ER proteostasis > Protein transport > TRAP complex component
• Why interesting: Good example where PN context is compatible with existing ER targeting/translocation GO terms
• Suggested next step: Add to boundary/phase1 tracking as a mapping positive control
• Related project: ER_PHAGY.md

PN Projection Rows

• GO:0015031 protein transport - entailed_by_goa_closure; scope=ok_for_propagation_to_go; mapping=er_proteostasis.yaml; PN=ER proteostasis|Protein transport|TRAP complex component

PN Dossier Context

No phase-1 dossier exists for this priority-only gene. This note preserves the current PROTEOSTASIS boundary or exception decision and should be superseded by a dossier section if the gene is promoted into a full phase-1 batch.

Note

This file is generated from the current PROTEOSTASIS priority table, PN projection outputs, and local gene-review artifacts. Edit those source records rather than this generated note when correcting the underlying curation.