PMID:26268547

Soybean transcription factor ORFeome associated with drought resistance: a valuable resource to accelerate research on abiotic stress resistance

C6T1A2 (Glyma17g18110.1) was cloned as part of a soybean transcription factor ORFeome. The study identified transcription factor genes associated with drought resistance in soybean, providing the nucleotide sequence for this C2H2-Zn transcription factor.

UniProtKB:C6T1A2

UniProtKB entry C6T1A2 (C6T1A2_SOYBN), C2H2-Zn transcription factor, Glycine max.

210-aa unreviewed (TrEMBL) protein with a single C2H2-type zinc finger domain (residues 79-106), two disordered regions, and an N-terminal acidic compositional bias. Keywords include Metal-binding, Zinc, and Zinc-finger.
InterPro classifies the protein in IPR053266 (Zinc_finger_protein_7), IPR036236 (Znf_C2H2_sf), and IPR013087 (Znf_C2H2_type). PANTHER classifies it as PTHR47593:SF9 (C2H2-TYPE DOMAIN-CONTAINING PROTEIN) within the ZINC FINGER PROTEIN 4-LIKE family (PTHR47593).
The only GO annotation in the UniProt DR lines is GO:0008270 (zinc ion binding, IEA:UniProtKB-KW), derived from the Zinc keyword. No annotations appear in the GOA QuickGO export.

file:SOYBN/C6T1A2/C6T1A2-deep-research-falcon.md

Deep-research report (falcon / Edison Scientific Literature) - functional annotation of soybean C6T1A2 / Glyma17g18110.1 (C6T1A2).

No gene-specific experimental literature was identified for C6T1A2 / Glyma17g18110.1 from soybean. The gene symbol C6T1A2 is a UniProt accession, not a conventional gene name, making literature searching difficult.
Based on InterPro domain annotation showing C2H2-type zinc finger domains (IPR013087, IPR036236, IPR053266), this protein is predicted to function as a DNA-binding transcription factor localized to the nucleus.

file:SOYBN/C6T1A2/C6T1A2-hypotheses/core-function-1-go-0003700/openscientist.md

OpenScientist hypothesis investigation - DNA-binding transcription factor activity

GO:0003700 annotation strongly supported by convergent computational, structural, and phylogenetic evidence. QALGGH motif is diagnostic for Q-type C2H2 ZFP transcription factors. Protein is officially designated soybean ZFP1 (NCBI Gene 732609). EAR repression motif suggests transcriptional repressor function.
None of the 11 soybean ZFP7 family members currently carry GO:0003700 in UniProt, suggesting a systematic annotation gap.

file:SOYBN/C6T1A2/C6T1A2-protnlm-predictions-review.yaml

ProtNLM2 prediction review for C6T1A2 - nucleus and ABA signaling predictions.

ProtNLM2 predicted GO:0005634 (nucleus) with high confidence (0.97), assessed as CNN (correct but not novel) since nuclear localization is trivially expected for a C2H2-type zinc finger transcription factor.
ProtNLM2 predicted GO:0009788 (negative regulation of abscisic acid-activated signaling pathway), assessed as UNC (uncertain). The prediction is a plausible phmmer-based transfer from Arabidopsis ZFP7 (Q39266) which shares IPR053266 family membership, but the C2H2 zinc finger family is functionally diverse and the specific ABA role may not be conserved.