ced-6 notes

Deep research status (2026-10-05)

No provider deep-research file exists for this gene. Providers were unavailable in this environment (Falcon returned 402, the OpenAI key was invalid, perplexity was not installed), as for ced-1 and MEGF10. The synthesis below was made by hand from cached publications. Every claim carries an inline citation and quote.

Identity

• UniProtKB:O76337 (F56D2.7), the orthologue of human GULP1. It has an N-terminal PTB domain and a proline/serine-rich C-terminal half PMID:9635426.
• It dimerizes PMID:10734103.
• PANTHER: UniProt and PANTHER's own classification agree, placing it in PTHR11232:SF77 (unlike ced-1). Its IBA engulfment node in the module is PTN000132688.

Core: CED-1 signaling adaptor in engulfing cells

• It acts in the engulfing cell PMID:9635426.
• Its PTB domain binds the NPXY motif of CED-1 PMID:11729193. This was confirmed with point mutants PMID:35929733.
• Actin reorganization PMID:15744306.
• Clathrin/AP2 hub PMID:23696751. The authors' model is an actin hub, not vesicle cargo loading PMID:23696751.
• Receptor turnover PMID:35929733.

Death-promoting role (non-core)

• Engulfment genes promote death of weakly signalled cells PMID:11449278. Also PMID:11449279.
• The Denning 2013 and Chen 2013 (CED-8) papers use ced-6(n2095) only as a clearance-defective background PMID:23505386. This is the background-genotype variant of the clearance-defect pattern in projects/APOPTOSIS/ASSAY_READOUT_OVERANNOTATION.md.
• 6-OHDA neurodegeneration PMID:29346382. This is not annotated in GOA and is not proposed: it is a consequence of the engulfment role.

Wnt paper (Cabello 2010)

• The spindle, left/right and DTC IGIs with mom-5 are over-annotations. The paper reports a role for the CED-1/6/7 branch in DTC migration as PMID:20126385, and no ced-6 spindle phenotype.

Round 6 of projects/INVOLVED_IN_PRECOMPOSITION.md (2026-11-10): the two GO:1902742 MODIFY replacements and the two GOA GO:1904747 rows (previously KEEP_AS_NON_CORE, now MODIFY) now use GO:0043065 positive regulation of apoptotic process instead of the precomposed GO:1904747 positive regulation of apoptotic process involved in development, with decomposed_into.context_dropped. The sign correction (the gene promotes death from the engulfing cell rather than taking part in the dying cell's program) is unchanged; only the developmental context is dropped. Earlier mentions of GO:1904747 above are superseded.