Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Iron-sulfur cluster biosynthesis. Characterization of frataxin as an iron donor for assembly of [2Fe-2S] clusters in ISU-type proteins.
Frataxin-mediated iron delivery to ferrochelatase in the final step of heme biosynthesis.
Iron-sulfur protein maturation in human cells: evidence for a function of frataxin.
Supramolecular assemblies of human frataxin are formed via subunit-subunit interactions mediated by a non-conserved amino-terminal region.
Assembly of human frataxin is a mechanism for detoxifying redox-active iron.
Frataxin interacts functionally with mitochondrial electron transport chain proteins.
Extra-mitochondrial localisation of frataxin and its association with IscU1 during enterocyte-like differentiation of the human colon adenocarcinoma cell line Caco-2.
A pool of extramitochondrial frataxin that promotes cell survival.
N-terminal iron-mediated self-cleavage of human frataxin: regulation of iron binding and complex formation with target proteins.
In vivo maturation of human frataxin.
The effects of frataxin silencing in HeLa cells are rescued by the expression of human mitochondrial ferritin.
Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia.
Dynamics, stability and iron-binding activity of frataxin clinical mutants.
The in vivo mitochondrial two-step maturation of human frataxin.
Molecular control of the cytosolic aconitase/IRP1 switch by extramitochondrial frataxin.
Mammalian frataxin: an essential function for cellular viability through an interaction with a preformed ISCU/NFS1/ISD11 iron-sulfur assembly complex.
Human frataxin activates Fe-S cluster biosynthesis by facilitating sulfur transfer chemistry.
Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly.
Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery.
Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions.
Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex.
Iron Sulfur and Molybdenum Cofactor Enzymes Regulate the Drosophila Life Cycle by Controlling Cell Metabolism.
Interactions of iron-bound frataxin with ISCU and ferredoxin on the cysteine desulfurase complex leading to Fe-S cluster assembly.
Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Mechanism and structural dynamics of sulfur transfer during de novo [2Fe-2S] cluster assembly on ISCU2.
Studies of human, mouse and yeast homologues indicate a mitochondrial function for frataxin.
Frataxin is reduced in Friedreich ataxia patients and is associated with mitochondrial membranes.
FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster
Mitochondrial iron-sulfur cluster biogenesis
Frataxin transfers Fe2+ to ACO2
Transfer of Fe-S clusters to SDHB
2Fe-2S is inserted in UQCRFS1
Deep research report on FXN
Mammalian frataxin directly enhances sulfur transfer of NFS1 persulfide to both ISCU and free thiols.
Mammalian frataxin controls sulfur production and iron entry during de novo Fe4S4 cluster assembly.