Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Cloning of three novel neuronal Cdk5 activator binding proteins.
Identification of a common protein association region in the neuronal Cdk5 activator.
A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart.
Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint.
A human protein-protein interaction network: a resource for annotating the proteome.
A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2.
LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB.
Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation.
Defining the membrane proteome of NK cells.
A novel LZAP-binding protein, NLBP, inhibits cell invasion.
A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling.
Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity.
LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1).
Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking.
Caspase-mediated cleavage of C53/LZAP protein causes abnormal microtubule bundling and rupture of the nuclear envelope.
A proteome-scale map of the human interactome network.
Widespread macromolecular interaction perturbations in human genetic disorders.
CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A non-canonical scaffold-type E3 ligase complex mediates protein UFMylation.
The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3.
Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control.
UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.
The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons.
Multimodal cell maps as a foundation for structural and functional genomics.