Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover.
SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development.
A High-Density Map for Navigating the Human Polycomb Complexome.
Dimerization quality control ensures neuronal development and survival.
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SCF(FBXL17) selectively binds and ubiquitinates BTB dimers of aberrant composition for proteasomal clearance (dimerization quality control, DQC); this activity is required for differentiation, function, and survival of neural crest and neuronal cells.
The FBXL family of F-box proteins: variations on a theme.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
FBXL17/spastin axis as a novel therapeutic target of hereditary spastic paraplegia.
Multimodal cell maps as a foundation for structural and functional genomics.
FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))
BACH1:FBXL17 binds SCF(SKP2) complex
Falcon deep research report for human FBXL17
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FBXL17 is the SCF (SKP1-CUL1-RBX1) substrate-recognition subunit, using an F-box to assemble the SCF and a C-terminal LRR to bind substrates for ubiquitination and proteasomal degradation.
"In this paradigm, **FBXL17 is the substrate receptor** that helps determine which proteins are ubiquitinated and often targeted for proteasomal degradation."
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FBXL17 does not engage the intact BACH1 BTB dimer; under oxidative/nitrosative stress it recognizes a compromised/destabilized BTB dimer and remodels it into ubiquitinated monomers, in contrast to FBXO22 which reads the intact cross-protomer degron.
"Under oxidative/nitrosative stress, **FBXL17 can recognize a compromised/destabilized BTB dimer and remodel it into monomers** that are ubiquitinated."
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SCF(FBXL17) targets the Hedgehog pathway tumor suppressor SUFU for nuclear proteolysis, enabling GLI activation and Hedgehog signal transduction.
"FBXL17 forms a functional SCF complex and targets the Hedgehog pathway tumor suppressor **SUFU (Suppressor of fused)** for **proteolysis in the nucleus**, enabling release/activation of GLI transcription factors and Hedgehog signal transduction."
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PRMT1 is a PTM-gated FBXL17 substrate; p300 acetylation at K228 creates an acetyl-degron that promotes FBXL17 binding and K48-linked polyubiquitination.
"PRMT1 is regulated by SCF(FBXL17) such that **p300-mediated acetylation at PRMT1 K228** promotes FBXL17 binding, **K48-linked polyubiquitination**, and proteasomal degradation."
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In neuronal models SCF(FBXL17) targets the long spastin isoform SPAST-M1 for proteasomal degradation via recognition of its N-terminal BTB domain.
"SCF(FBXL17) targets **SPAST-M1** (long spastin isoform) for **proteasome-dependent degradation in the nuclear fraction**, with substrate recognition mediated by the **SPAST N-terminal BTB domain**."