Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling.
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Mapping of LAT tyrosines: Y132 for PLCG1; Y171/Y191/Y226 for GRB2; Y171/Y191 for GADS
"Upon T cell activation, LAT becomes highly phosphorylated on tyrosine residues, and Grb2, Gads, and phospholipase C (PLC)-gamma1 bind LAT via Src homology-2 domains."
Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells.
Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav.
CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling.
Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains.
The tyrosine phosphatase 1B regulates linker for activation of T-cell phosphorylation and platelet aggregation upon FcgammaRIIa cross-linking.
T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression.
The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB.
Control of TCR-mediated activation of beta 1 integrins by the ZAP-70 tyrosine kinase interdomain B region and the linker for activation of T cells adapter protein.
Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes.
Fine specificity and molecular competition in SLAM family receptor signalling.
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.
A proteome-scale map of the human interactome network.
The Us3 Protein of Herpes Simplex Virus 1 Inhibits T Cell Signaling by Confining Linker for Activation of T Cells (LAT) Activation via TRAF6 Protein.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.
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Cloning of LAT as a ZAP70/Syk-phosphorylated integral membrane protein that recruits signaling molecules
"We show that this protein is phosphorylated by ZAP-70/Syk protein tyrosine kinases leading to recruitment of multiple signaling molecules."
LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation.
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Palmitoylation at C26/C29 targets LAT to GEMs/rafts
"Although the LAT transmembrane domain is sufficient for membrane localization, palmitoylation at C26 and C29 is essential for efficient partitioning into GEMs."
Recruitment of PLC-gamma1 to LAT
Phosphorylation of SLP-76
Recruitment of SLP-76 to Gads
Phosphorylation of TBSMs in LAT
Phosphorylation of PLC-gamma1
Recruitment of Gads to LAT
Recruitment of PLC-gamma1 to SLP-76
Recruitment of ITK to SLP-76
Disassociation of PLC-gamma1 from LAT
Disassociation of PLC-gamma1 from SLP-76
Phosphorylation of LAT by p-SYK
Recruitment of GADS:SLP-76 to p-5Y-LAT
Phosphorylation of SLP-76 by p-SYK
Recruitment of GRB2:SOS to p-5Y-LAT
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT
Activation of RAC1 by VAV2/3
SOS mediated nucleotide exchange of RAS (SHC)
Recruitment of VAV and BTK to p-SLP-76
Phosphorylation of BTK by p-SYK
Phosphorylation and activation of VAV2/VAV3 by SYK
Phosphorylation of PLC-gamma by p-BTK/p-SYK
Phosphorylation of TEC kinases by p-SYK
Activation of RAC1 by VAV
Phosphorylation and activation of VAV
Phosphorylation of LAT by p-SYK
Hydrolysis of PIP2 by PLCG
Phosphorylation of SLP-76 by p-SYK
Autophosphorylation of PAK
Autophosphorylation of BTK/ITK
Recruitment of PAK to the membrane by binding active RAC1
Recruitment of VAV to p-SLP-76
Syk/Lck phosphorylate LAT
RAS GEFs promote RAS nucleotide exchange
Phase separation of signaling molecules promotes T cell receptor signal transduction.
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Phospho-LAT forms liquid-like phase-separated signaling clusters
"These results show that pLAT microclusters are liquid-like, phase-separated structures (17, 18) on membranes."
LAT is essential for Fc(epsilon)RI-mediated mast cell activation.
LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI.
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LAT is required for GPVI-induced PLCgamma2 activation in platelets
"they establish a major role for LAT in the phosphorylation and activation of PLCgamma2, leading to downstream responses such as alpha-granule secretion and activation of integrin alpha(IIb)beta(3)."
Essential role of LAT in T cell development.
Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT.
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Human LAT deficiency causes combined immunodeficiency with autoimmunity
"The adapter protein linker for activation of T cells (LAT) is a critical signaling hub connecting T cell antigen receptor triggering to downstream T cell responses."
TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapter.
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TRAF6 K63-ubiquitinates LAT at K88
"Moreover, LAT was ubiquitinated at Lys(88) by TRAF6 via K63-linked chain."
Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling.
The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells.
The type 1 cysteinyl leukotriene receptor triggers calcium influx and chemotaxis in mouse alpha beta- and gamma delta effector T cells.
Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation.
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Surface LAT is recruited and phosphorylated first in microclusters; the vesicular LAT pool is recruited to the synapse later
"We propose a model in which cell surface LAT is recruited rapidly and phosphorylated at sites of T-cell activation, while the vesicular pool is subsequently recruited and dynamically interacts with microclusters."
VAMP7 controls T cell activation by regulating the recruitment and phosphorylation of vesicular Lat at TCR-activation sites.
Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation.
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Internalized LAT transits through the Golgi-TGN via Rab6/syntaxin-16-dependent retrograde transport before repolarization to the immune synapse
"We show herein that LAT, once internalized, transits through the Golgi-trans-Golgi network (TGN), where it is repolarized to the immune synapse."
Retrograde and Anterograde Transport of Lat-Vesicles during the Immunological Synapse Formation: Defining the Finely-Tuned Mechanism.
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LAT is more abundant on intracellular membranes than at the plasma membrane; syntaxin-16 controls retrograde and VAMP7 anterograde LAT transport, with the Golgi as hub
"This adapter molecule is present at the plasma membrane of T lymphocytes and more abundantly in intracellular compartments."
Falcon deep research report for human LAT