GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

PMID:10618370

Signal recognition particle components in the nucleolus.

SRP19 binds SRP RNA independently and must bind before SRP54, effecting a conformational change promoting SRP54 binding; GFP-SRP19 shows prominent nucleolar plus cytoplasmic localization.

PMID:11682607

Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin.

SRP19 is efficiently imported into the nucleus by importin 8 and transportin; a significant endogenous pool is nuclear/nucleolar.

PMID:1678319

Identification of deletion mutations and three new genes at the familial polyposis locus.

Positional cloning at the APC/polyposis locus identified a gene identical to SRP19, the 19 kDa component of the ribosomal signal recognition particle.

PMID:17434535

A threefold RNA-protein interface in the signal recognition particle gates native complex assembly.

SRP19 is unstructured when free and folds into a compact core plus two extended RNA-binding loops upon binding SRP RNA; SRP54 subsequently binds the assembled SRP19-RNA complex.

PMID:18089836

A new mechanism of 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by target screening with drug-immobilized affinity beads.

SRP is the target of TAS-103; the compound disrupts SRP complex formation and reduces the amount of SRP14 and SRP19, detecting SRP19 within the SRP complex.

PMID:22658674

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.

PMID:27899666

Structures of human SRP72 complexes provide insights into SRP RNA remodeling and ribosome interaction.

SRP19 is a scaffolding protein clamping helices 6 and 8 of SRP RNA, preparing the asymmetric loop of helix 8 for SRP54 binding; SRP72-RBD remodels the 5f-loop involved in ribosome binding.

PMID:33961781

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

PMID:34208095

SRPassing Co-translational Targeting: The Role of the Signal Recognition Particle in Protein Targeting and mRNA Protection.

SRP19 functions to stabilize the 7SL RNA structure within SRP; SRP consists of Alu and S domains with six proteins and 7SL RNA.

PMID:35271311

OpenCell: Endogenous tagging for the cartography of human cellular organization.

Reactome:R-HSA-1799332

Reactome: Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)

PMID:12086622

Crystal structure of SRP19 in complex with the S domain of SRP RNA and its implication for the assembly of the signal recognition particle.

Crystal structure of SRP19 bound to the S-domain of SRP RNA shows SRP19 clamps the tetraloops of helices 6 and 8 (helix 6 acting as a splint), pre-organizing the SRP54-binding site on helix 8; unlike bacterial systems, human SRP54 cannot bind SRP RNA before SRP19, establishing SRP19 as an upstream eukaryotic assembly factor.

PMID:38858088

The nucleolar phase of signal recognition particle assembly.

GFP-SRP19 accumulates in nucleoli and co-localizes with nucleolar markers; nucleolar disruption (low-dose actinomycin D, uL18/RPL5 depletion) relocalizes SRP19, and SRP proteins associate with many nucleolar/ribosome-biogenesis factors, supporting a bona fide nucleolar phase of SRP assembly.

PMID:35754847

Signal Recognition Particle in Human Diseases.

Reviews SRP-related human disease; SRP19 is among the SRP autoantigens (anti-SRP19, anti-SRP54, anti-SRP72, anti-7SL) recognized in immune-mediated necrotizing myopathy (IMNM)/anti-SRP myositis.

file:human/SRP19/SRP19-uniprot.txt

UniProt entry P09132 (SRP19_HUMAN), Signal recognition particle 19 kDa protein

SRP19 is a subunit of the SRP ribonucleoprotein (7SL RNA + six proteins); binds directly to 7SL RNA and mediates binding of SRP54 to the SRP complex; cytoplasmic with nuclear/nucleolar assembly pools.