Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains.
Directed discovery of bivalent peptide ligands to an SH3 domain.
FGF negatively regulates muscle membrane extension in Caenorhabditis elegans.
Functional Coordination of WAVE and WASP in C. elegans Neuroblast Migration.
The lin-3/let-23 pathway mediates inductive signalling during male spicule development in Caenorhabditis elegans.
The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5.
The adaptor protein soc-1/Gab1 modifies growth factor receptor output in Caenorhabditis elegans.
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In vulval induction the C-terminal SH3 domain of SEM-5 acts positively, beyond recruiting SOC-1/Gab1
"Consistent with this, in the vulval induction assay for Egfr/Ras/Map kinase signaling, the C-terminal SH3 domain of sem-5 /Grb2 has additional positive functions beyond recruiting Gab1 ( Table 1 )."
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sem-5(n2195) weakly suppresses the let-60(gf) multivulva phenotype
"However, previous studies have shown that both a null mutation in ptp-2 and sem-5(n2195) G201R weakly suppress the multi-vulva phenotype of let-60(n1046gf) mutant animals"
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SOC-1 binds the SEM-5 C-terminal SH3 domain; its recruitment enhances Ras/MAPK signaling and inhibits PI3K- and PLC-gamma-mediated signaling
"Thus, the recruitment of soc-1/Gab1, and its effectors, into the RTK-signaling complex modifies the cellular response by enhancing Ras/Map kinase signaling while inhibiting PI3K and PLCγ-mediated signaling."
Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans.
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sem-5(n1779), like other positive regulators of EGL-15 FGF signaling, confers moderate nicotine resistance
"as well as mutations in three additional positive regulators of FGF signaling, soc-2(ku167) , sos-1(c548) , and sem-5(n1779) , caused moderate nicotine resistance"
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The drug resistance of these FGF pathway mutants correlates with reduced synaptic LEV-1 levels
"Importantly, the drug response phenotypes observed for the mutants in egl-15 and other positive FGF signaling regulators correlated with a reduction of synaptic LEV-1∷4xHA expression, just like in soc-1(n1789) ( Figure 7C ; Supplementary Figure 4B )."
UniProt entry P29355 (SEM5_CAEEL)
WormBase gene description for sem-5 (worm)