Falcon deep research report for AZI2
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AZI2/NAP1 is a scaffold/adaptor (not an enzyme) that binds TBK1 and promotes its activation via adaptor-driven assembly/oligomerization and TBK1 Ser172 autophosphorylation, linking TBK1 to multiple signaling platforms and cargo-receptor complexes (innate immunity, selective autophagy/mitophagy, TNF signaling, mitosis).
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling.
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NAP1 interacts with the IKK-related kinases NAK/TBK1 and IKBKE/IKKepsilon, activates TBK1 and facilitates its oligomerization, and the NAK-NAP1 complex phosphorylates Ser536 of p65/RELA; NAP1 potentiates NF-kappaB-dependent gene expression and localizes to the cytoplasm.
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.
NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction.
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7.
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Vaccinia virus C6 binds the TBK1 adaptor proteins (NAP1, TANK, SINTBAD) and inhibits IRF3/IRF7 activation, identifying NAP1 as a TBK1 adaptor targeted by a viral immune antagonist.
Flavivirus NS3 and NS5 proteins interaction network: a high-throughput yeast two-hybrid screen.
Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a Positive Regulator of SeV-Induced Innate Immunity.
Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.