Properties of the NAD(P)H-dependent xylose reductase from the xylose-fermenting yeast Pichia stipitis
Cloning and expression in Saccharomyces cerevisiae of the NAD(P)H-dependent xylose reductase-encoding gene (XYL1) from the xylose-assimilating yeast Pichia stipitis
Genome sequence of the lignocellulose-bioconverting and xylose-fermenting yeast Pichia stipitis
Structural insight into D-xylose utilization by xylose reductase from Scheffersomyces stipitis
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NADPH-bound crystal structure confirms cofactor binding and an open/closed conformational change on NADPH binding
"We also determined the SsXR structure in complex with the NADPH cofactor and revealed that the protein undergoes an open/closed conformation change upon NADPH binding"
Deep research synthesis from multiple sources including structural studies (PMID:30416116)
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Crystal structure revealed TIM-barrel fold and NADPH-binding
"Crystal structure at 1.95Å resolution revealed TIM-barrel fold, NADPH-binding site, and conformational changes upon cofactor binding"
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods.