PANTHER PTHR11514 MYC/bHLH family context
PANTHER PTHR11514 MYC/bHLH family context
Falcon deep research report for Arabidopsis MYC2
UniProtKB record for Arabidopsis MYC2
Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity.
MYC2 differentially modulates diverse jasmonate-dependent functions in Arabidopsis.
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MYC2 negatively regulates tryptophan and indole-glucosinolate metabolism during jasmonate signaling.
"We found that MYC2 negatively regulates Trp and Trp-derived secondary metabolism such as indole glucosinolate biosynthesis during JA signaling."
The JAZ family of repressors is the missing link in jasmonate signalling.
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JAZ/JAI3 repression regulates MYC2 within the core jasmonate pathway.
"Moreover, JAI3 negatively regulates the key transcriptional activator of jasmonate responses, MYC2."
A downstream mediator in the growth repression limb of the jasmonate pathway.
A critical role of two positively charged amino acids in the Jas motif of Arabidopsis JAZ proteins in mediating coronatine- and jasmonoyl isoleucine-dependent interactions with the COI1 F-box protein.
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JAZ1 and JAZ9 interact with MYC2 even when residues required for COI1 recognition are mutated.
"Mutations of these two residues did not affect the ability of JAZ1 and JAZ9 to interact with the transcription factor AtMYC2."
The ZIM domain mediates homo- and heteromeric interactions between Arabidopsis JAZ proteins.
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Pull-down and yeast two-hybrid assays establish JAZ-MYC2 binding.
"we show that interaction with MYC2 is a common feature of the JAZ family, as most JAZ proteins can bind MYC2 in pull-down and yeast two-hybrid assays."
The bHLH transcription factor MYC3 interacts with the Jasmonate ZIM-domain proteins to mediate jasmonate response in Arabidopsis.
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MYC2 mediates jasmonate responses including inhibition of root growth.
"The bHLH transcription factor MYC2 was found to interact with JAZs and mediate JA responses including JA-inhibitory root growth."
Characterization of JAZ-interacting bHLH transcription factors that regulate jasmonate responses in Arabidopsis.
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MYC2 directly activates a JAZ promoter reporter in transfected protoplasts.
"MYC2, MYC3, and MYC4 were all capable of inducing expression of JAZ::GUS reporter constructs following transfection of carrot protoplasts."
Derepression of ethylene-stabilized transcription factors (EIN3/EIL1) mediates jasmonate and ethylene signaling synergy in Arabidopsis.
Transcription factor-dependent nuclear localization of a transcriptional repressor in jasmonate hormone signaling.
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MYC2 interaction contributes to nuclear targeting of JAZ repressors.
"physical interaction with MYC2 appears to play an active role in the nuclear targeting of JAZ1 and JAZ9, and the nuclear localization of JAZ9 was compromised in myc2 mutant plants."
Interaction between MYC2 and ETHYLENE INSENSITIVE3 modulates antagonism between jasmonate and ethylene signaling in Arabidopsis.
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MYC2 binds EIN3 and represses its transcriptional activity, mediating JA/ET antagonism.
"MYC2 interacts with EIN3 to attenuate the transcriptional activity of EIN3 and repress ET-enhanced apical hook curvature."
Inverse modulation of the energy sensor Snf1-related protein kinase 1 on hypoxia adaptation and salt stress tolerance in Arabidopsis thaliana.
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AKIN10 controls MYC2 abundance through kinase-dependent modification and proteasome activity.
"Biochemical analyses showed that AKIN10 negatively modulates AtMYC2 protein accumulation via proteasome activity upon AKIN10 kinase activity-dependent protein modification."
Promoter-based integration in plant defense regulation.
Virulence factors of geminivirus interact with MYC2 to subvert plant resistance and promote vector performance.
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MYC2 directly binds a G-box-like element in the TPS10 promoter, with sequence-mutant controls.
"His-MYC2 can bind to G-box-like 2 (CACATG) but not to G-box-like 1 (CAAGTG) nor to a mutant of G-box-like 2 (TTCAAA)"
An Arabidopsis gene regulatory network for secondary cell wall synthesis.
Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling.
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The study directly maps a JAZ9-interacting region in MYC2 as well as MYC3/MYC4; MYC3-focused structural results do not imply MYC2 was untested.
"A conserved ~200 amino acid (aa 55-259, aa 44-234 and aa 55-253 in MYC2, MYC3 and MYC4, respectively) region within the N-termini of all three proteins that encompasses the previously defined JAZ-interacting domain (JID)13,14 and the transcription activation domain (TAD)13,15 was sufficient to interact with JAZ9"
An ABA-increased interaction of the PYL6 ABA receptor with MYC2 Transcription Factor: A putative link of ABA and JA signaling.
Establishment of Expression in the SHORTROOT-SCARECROW Transcriptional Cascade through Opposing Activities of Both Activators and Repressors.
Crystal Structure of Tetrameric Arabidopsis MYC2 Reveals the Mechanism of Enhanced Interaction with DNA.
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MYC2 binds G-box DNA as a tetramer in the crystal structure.
"Here, we report the 2.7 Å crystal structure of the MYC2 bHLH domain complexed with G-box DNA, showing a cis-tetrameric structure."
CrY2H-seq: a massively multiplexed assay for deep-coverage interactome mapping.
Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
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MYC2/3/4 redundantly mediate jasmonate-dependent inhibition of stomatal development.
"three MYC transcription factors involved in jasmonate signaling, MYC2, MYC3, and MYC4, were found to redundantly modulate jasmonate-inhibited stomatal development."
Blue Light Regulates Secondary Cell Wall Thickening via MYC2/MYC4 Activation of the NST1-Directed Transcriptional Network in Arabidopsis.
Extracellular ATP Shapes a Defense-Related Transcriptome Both Independently and along with Other Defense Signaling Pathways.
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MYC transcription factors contribute to transcriptional responses downstream of extracellular ATP perception.
"We further tested the ATP-induced genes in knockout mutants of transcription factors, demonstrating that MYCs acting downstream of the jasmonate receptor complex and calmodulin-binding transcription activators are nuclear transducers of P2K1-mediated extracellular ATP signaling."
A point-to-point protein-protein interaction assay reveals the signaling interplays among plant hormones and environmental cues.
Extensive signal integration by the phytohormone protein network.
Jasmonate induces translation of the Arabidopsis transfer RNA-binding protein YUELAO1, which activates MYC2 in jasmonate signaling.
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YL1 physically interacts with and activates MYC2.
"Once translated, YL1 acts as an activator of the MYC2 transcription factor through direct interaction"
Role of arabidopsis MYC and MYB homologs in drought- and abscisic acid-regulated gene expression.
Reversible protein phosphorylation regulates jasmonic acid-dependent and -independent wound signal transduction pathways in Arabidopsis thaliana.
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The jin1 mutant disrupts jasmonate-responsive transcription in a wound-signaling study.
"JA activation via this pathway was blocked in the A. thaliana JA-insensitive mutants jin1, jin4 and coi1"