Gene Ontology annotation through association of InterPro records with GO terms

Gene Ontology annotation based on Enzyme Commission mapping

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

Automatic Gene Ontology annotation based on Rhea mapping

CDKL5 belongs to the same molecular pathway of MeCP2 and it is responsible for the early-onset seizure variant of Rett syndrome.

Functional consequences of mutations in CDKL5, an X-linked gene involved in infantile spasms and mental retardation.

Protein interactome reveals converging molecular pathways among autism disorders.

CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons.

HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder.

Architecture of the human interactome defines protein communities and disease networks.

CDKL5 localizes at the centrosome and midbody and is required for faithful cell division.

CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function.

Phosphoproteomic screening identifies physiological substrates of the CDKL5 kinase.

A reference map of the human binary protein interactome.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

CDKL5 kinase controls transcription-coupled responses to DNA damage.

Chemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics.

CDKL5, a protein associated with rett syndrome, regulates neuronal morphogenesis via Rac1 signaling.

Characterisation of CDKL5 Transcript Isoforms in Human and Mouse.

A novel transcript of cyclin-dependent kinase-like 5 (CDKL5) has an alternative C-terminus and is the predominant transcript in brain.

CDKL5 bounded machine-source evidence extract

ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks.

DNAPKcs-dependent arrest of RNA polymerase II transcription in the presence of DNA breaks.