Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The small GTPase RalA targets filamin to induce filopodia.
Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas.
Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein.
SPECs, small binding proteins for Cdc42.
The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42.
A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes.
Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C.
Borg proteins control septin organization and are negatively regulated by Cdc42.
The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading.
Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE.
Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6.
The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling.
Identification and characterization of the Cdc42-binding site of IQGAP1.
RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo.
Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.
Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs.
The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs.
Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding.
Activation of endogenous Cdc42 visualized in living cells.
TIM, a Dbl-related protein, regulates cell shape and cytoskeletal organization in a Rho-dependent manner.
Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.
A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis.
Towards a proteome-scale map of the human protein-protein interaction network.
Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP.
Sec14 homology domain targets p50RhoGAP to endosomes and provides a link between Rab and Rho GTPases.
Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter.
The crystal structure of Cdc42 in complex with collybistin II, a gephyrin-interacting guanine nucleotide exchange factor.
Role of RacC for the regulation of WASP and phosphatidylinositol 3-kinase during chemotaxis of Dictyostelium.
Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element.
Actin pedestal formation by enteropathogenic Escherichia coli is regulated by IQGAP1, calcium, and calmodulin.
AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication.
Adiponectin promotes migration activities of endothelial progenitor cells via Cdc42/Rac1.
Role of Kenae/CCDC125 in cell motility through the deregulation of RhoGTPase.
Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis.
Defining the membrane proteome of NK cells.
Ubc9 promotes breast cell invasion and metastasis in a sumoylation-independent manner.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.
Regulation of mixed lineage kinase 3 is required for Neurofibromatosis-2-mediated growth suppression in human cancer.
A human MAP kinase interactome.
EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation.
ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2.
The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42.
Invasion of breast cancer cells into collagen matrix requires TGF-α and Cdc42 signaling.
Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization.
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
Interaction of the Salmonella Typhimurium effector protein SopB with host cell Cdc42 is involved in intracellular replication.
Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2).
ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion.
Quantitative mass spectrometry catalogues Salmonella pathogenicity island-2 effectors and identifies their cognate host binding partners.
IQGAP1 is a novel CXCR2-interacting protein and essential component of the "chemosynapse".
A directed protein interaction network for investigating intracellular signal transduction.
Toward an understanding of the protein interaction network of the human liver.
Three-dimensional reconstruction of protein networks provides insight into human genetic disease.
Group I and II mammalian PAKs have different modes of activation by Cdc42.
Protein tyrosine phosphatase α phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions.
Tetraspanin CD151 stimulates adhesion-dependent activation of Ras, Rac, and Cdc42 by facilitating molecular association between β1 integrins and small GTPases.
Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex.
Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis.
Histaminylation of glutamine residues is a novel posttranslational modification implicated in G-protein signaling.
Blebbishields, the emergency program for cancer stem cells: sphere formation and tumorigenesis after apoptosis.
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration.
The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1.
CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP.
Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease.
Coronin-1C and RCC2 guide mesenchymal migration by trafficking Rac1 and controlling GEF exposure.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
A proteome-scale map of the human interactome network.
A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations.
NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells.
Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration.
Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Association of dysfunctional synapse defective 1 (SYDE1) with restricted fetal growth - SYDE1 regulates placental cell migration and invasion.
LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.
Architecture of the human interactome defines protein communities and disease networks.
RIT1 controls actin dynamics via complex formation with RAC1/CDC42 and PAK1.
CDC42 Negatively Regulates Testis-Specific SEPT12 Polymerization.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
A reference map of the human binary protein interactome.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases.
Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I.
Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization.
Bni1p, a yeast formin linking cdc42p and the actin cytoskeleton during polarized morphogenesis.
Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization.
Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP.
The Cdc42/Rac interactive binding region motif of the Wiskott Aldrich syndrome protein (WASP) is necessary but not sufficient for tight binding to Cdc42 and structure formation.
Negative regulation of Rho family GTPases Cdc42 and Rac2 by homodimer formation.
Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix
CDC42:GTP binds CBL:Beta-Pix
An unknown GEF exchanges GTP for GDP on CDC42:GDP
Autophosphorylation of PAK1
RAC1 and CDC42 activate PAK1
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin
WIP binds WASP,N-WASP, activating them
Src phosphorylate WASP,N-WASP
Activation of Cdc42 by pVav1
Activation of PAKs by RAC1 and CDC42
N-WASP binds ARP2/3 and G-actin
CDC42 and PIP2 bind WASL, activating it
Recruitment and activation of N-WASP by Cdc42
Nuclear translocation of p38 MAPK
p38 MAPK activation by VEGFR
VEGF induces CDC42 activation by unknown mechanism
Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
GTP-bound RAC1 and CDC42 bind IQGAPs
IQGAPs bind F-actin, which is inhibited by calmodulin
Autophosphorylation of PAK1,2,3
CDC42:GTP:FMNL2 binds Profilin:G-actin
CDC42:GTP recruits DIAPH2-2 to kinetochores
AURKB phosphorylates DIAPH2-2 at kinetochores
IQGAP1 binds CLIP1 and microtubules
Expression of cell division cycle 42
CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85
Active PAK1 and Active CDC42 dissociates from GNB/GNG:PAK1:ARHGEF6:CDC42 complex
CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated
PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated
CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex
RAC1 and CDC42 activate PAK3
RAC1 and CDC42 activate PAK2
CDC42 binds effectors at the plasma membrane
CDC42 GDIs block activation of CDC42
CDC42 GEFs activate CDC42
CDC42 GAPs stimulate CDC42 GTPase activity
CDC42 translocates to the endoplasmic reticulum membrane
CDC42 binds effectors at the ER membrane
Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion.
The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6.