Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome.
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis.
PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2.
Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody.
Chk2 activates E2F-1 in response to DNA damage.
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta.
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit.
Human cytomegalovirus inhibits a DNA damage response by mislocalizing checkpoint proteins.
Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage.
Trans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchange.
Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes.
Che-1 phosphorylation by ATM/ATR and Chk2 kinases activates p53 transcription and the G2/M checkpoint.
Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage.
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites.
The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage.
Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379.
The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication.
ATM and Chk2 kinase target the p53 cofactor Strap.
Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair.
A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.
The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells.
Per3, a circadian gene, is required for Chk2 activation in human cells.
The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors.
The E3 ligase RNF8 regulates KU80 removal and NHEJ repair.
CHK2 kinase promotes pre-mRNA splicing via phosphorylating CDK11(p110).
PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair.
Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling.
Systematic identification of molecular links between core and candidate genes in breast cancer.
TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1.
A protein interaction landscape of breast cancer.
Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.
ATM-CHK2-TRIM32 axis regulates ATG7 ubiquitination to initiate autophagy under oxidative stress.
Proteome-scale characterisation of motif-based interactome rewiring by disease mutations.
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase.
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase.
Phosphorylation of MDM4 by CHEK2
CHEK2 is recruited to DNA DSBs
p-T68-CHEK2 autophosphorylates
CHEK2 phosphorylates BRCA1
DNA Double Strand Break Response
CHEK2 phosphorylates TTC5
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Activity through Methylation
Regulation of TP53 Expression and Degradation
p53-Dependent G1 DNA Damage Response
Phosphorylation of CDC25A by CHEK2
CHEK2 phosphorylates TP53
Phosphorylation and activation of CHEK2 by ATM
Phosphorylation of Cdc25C at Ser216 by CHEK2
A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage.
Alternative splicing and mutation status of CHEK2 in stage III breast cancer.
Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase.
CHEK2 authenticated source facts and primary-access ledger